Anti-DB133/ DEFB133 functional antibody

Anti-DB133/ DEFB133 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to DEFB133/DEFB133 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0879-Ab-1/ GM-Tg-hg-SE0879-Ab-2Anti-Human DEFB133 monoclonal antibodyHuman
GM-Tg-rg-SE0879-Ab-1/ GM-Tg-rg-SE0879-Ab-2Anti-Rat DEFB133 monoclonal antibodyRat
GM-Tg-mg-SE0879-Ab-1/ GM-Tg-mg-SE0879-Ab-2Anti-Mouse DEFB133 monoclonal antibodyMouse
GM-Tg-cynog-SE0879-Ab-1/ GM-Tg-cynog-SE0879-Ab-2Anti-Cynomolgus/ Rhesus macaque DEFB133 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0879-Ab-1/ GM-Tg-felg-SE0879-Ab-2Anti-Feline DEFB133 monoclonal antibodyFeline
GM-Tg-cang-SE0879-Ab-1/ GM-Tg-cang-SE0879-Ab-2Anti-Canine DEFB133 monoclonal antibodyCanine
GM-Tg-bovg-SE0879-Ab-1/ GM-Tg-bovg-SE0879-Ab-2Anti-Bovine DEFB133 monoclonal antibodyBovine
GM-Tg-equg-SE0879-Ab-1/ GM-Tg-equg-SE0879-Ab-2Anti-Equine DEFB133 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0879-Ab-1/ GM-Tg-hg-SE0879-Ab-2; GM-Tg-rg-SE0879-Ab-1/ GM-Tg-rg-SE0879-Ab-2;
GM-Tg-mg-SE0879-Ab-1/ GM-Tg-mg-SE0879-Ab-2; GM-Tg-cynog-SE0879-Ab-1/ GM-Tg-cynog-SE0879-Ab-2;
GM-Tg-felg-SE0879-Ab-1/ GM-Tg-felg-SE0879-Ab-2; GM-Tg-cang-SE0879-Ab-1/ GM-Tg-cang-SE0879-Ab-2;
GM-Tg-bovg-SE0879-Ab-1/ GM-Tg-bovg-SE0879-Ab-2; GM-Tg-equg-SE0879-Ab-1/ GM-Tg-equg-SE0879-Ab-2
Products NameAnti-DEFB133 monoclonal antibody
Formatmab
Target NameDEFB133
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DEFB133 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0879-Ag-1Recombinant multi-species DB133/ DEFB133 protein


    Target information

    Target IDGM-SE0879
    Target NameDEFB133
    Gene ID403339,114677749,112443755,111769227
    Gene Symbol and SynonymsDEFB133,DEFB134
    Uniprot AccessionQ30KQ1
    Uniprot Entry NameDB133_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000214643
    Target ClassificationN/A

    The target: DEFB133, gene name: DEFB133, also named as . Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.