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Anti-CILP1/ CILP/ CILP-1 functional antibody
Anti-CILP1/ CILP/ CILP-1 functional antibody for cell culture, ELISA & in-vivo assay
Go to CILP/CILP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0779-Ab-1/ GM-Tg-hg-SE0779-Ab-2 | Anti-Human CILP monoclonal antibody | Human |
| GM-Tg-rg-SE0779-Ab-1/ GM-Tg-rg-SE0779-Ab-2 | Anti-Rat CILP monoclonal antibody | Rat |
| GM-Tg-mg-SE0779-Ab-1/ GM-Tg-mg-SE0779-Ab-2 | Anti-Mouse CILP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0779-Ab-1/ GM-Tg-cynog-SE0779-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CILP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0779-Ab-1/ GM-Tg-felg-SE0779-Ab-2 | Anti-Feline CILP monoclonal antibody | Feline |
| GM-Tg-cang-SE0779-Ab-1/ GM-Tg-cang-SE0779-Ab-2 | Anti-Canine CILP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0779-Ab-1/ GM-Tg-bovg-SE0779-Ab-2 | Anti-Bovine CILP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0779-Ab-1/ GM-Tg-equg-SE0779-Ab-2 | Anti-Equine CILP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0779-Ab-1/ GM-Tg-hg-SE0779-Ab-2; GM-Tg-rg-SE0779-Ab-1/ GM-Tg-rg-SE0779-Ab-2; GM-Tg-mg-SE0779-Ab-1/ GM-Tg-mg-SE0779-Ab-2; GM-Tg-cynog-SE0779-Ab-1/ GM-Tg-cynog-SE0779-Ab-2; GM-Tg-felg-SE0779-Ab-1/ GM-Tg-felg-SE0779-Ab-2; GM-Tg-cang-SE0779-Ab-1/ GM-Tg-cang-SE0779-Ab-2; GM-Tg-bovg-SE0779-Ab-1/ GM-Tg-bovg-SE0779-Ab-2; GM-Tg-equg-SE0779-Ab-1/ GM-Tg-equg-SE0779-Ab-2 |
| Products Name | Anti-CILP monoclonal antibody |
| Format | mab |
| Target Name | CILP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CILP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0779-Ag-1 | Recombinant multi-species CILP1/ CILP/ CILP-1 protein |
| Cytokine | GM-Tg-g-SE0779-Ag-1 | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) protein |
Target information
| Target ID | GM-SE0779 |
| Target Name | CILP |
| Gene ID | 8483,214425,315761,709042,487603,101084795,100336614,100053337 |
| Gene Symbol and Synonyms | 9830114D16,C130036G17Rik,CILP,CILP-1,CILP1,HsT18872 |
| Uniprot Accession | O75339 |
| Uniprot Entry Name | CILP1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000138615 |
| Target Classification | N/A |
The target: CILP, gene name: CILP, also named as CILP-1, HsT18872. Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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