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Anti-CAH11/ CA11/ CA-RP functional antibody
Anti-CAH11/ CA11/ CA-RP functional antibody for cell culture, ELISA & in-vivo assay
Go to CA11/CA11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0728-Ab-1/ GM-Tg-hg-SE0728-Ab-2 | Anti-Human CA11 monoclonal antibody | Human |
| GM-Tg-rg-SE0728-Ab-1/ GM-Tg-rg-SE0728-Ab-2 | Anti-Rat CA11 monoclonal antibody | Rat |
| GM-Tg-mg-SE0728-Ab-1/ GM-Tg-mg-SE0728-Ab-2 | Anti-Mouse CA11 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0728-Ab-1/ GM-Tg-cynog-SE0728-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CA11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0728-Ab-1/ GM-Tg-felg-SE0728-Ab-2 | Anti-Feline CA11 monoclonal antibody | Feline |
| GM-Tg-cang-SE0728-Ab-1/ GM-Tg-cang-SE0728-Ab-2 | Anti-Canine CA11 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0728-Ab-1/ GM-Tg-bovg-SE0728-Ab-2 | Anti-Bovine CA11 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0728-Ab-1/ GM-Tg-equg-SE0728-Ab-2 | Anti-Equine CA11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0728-Ab-1/ GM-Tg-hg-SE0728-Ab-2; GM-Tg-rg-SE0728-Ab-1/ GM-Tg-rg-SE0728-Ab-2; GM-Tg-mg-SE0728-Ab-1/ GM-Tg-mg-SE0728-Ab-2; GM-Tg-cynog-SE0728-Ab-1/ GM-Tg-cynog-SE0728-Ab-2; GM-Tg-felg-SE0728-Ab-1/ GM-Tg-felg-SE0728-Ab-2; GM-Tg-cang-SE0728-Ab-1/ GM-Tg-cang-SE0728-Ab-2; GM-Tg-bovg-SE0728-Ab-1/ GM-Tg-bovg-SE0728-Ab-2; GM-Tg-equg-SE0728-Ab-1/ GM-Tg-equg-SE0728-Ab-2 |
| Products Name | Anti-CA11 monoclonal antibody |
| Format | mab |
| Target Name | CA11 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CA11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0728-Ag-1 | Recombinant multi-species CAH11/ CA11/ CA-RP protein |
| ORF Viral Vector | vGMLP000589 | human CA11 Lentivirus particle |
| ORF Viral Vector | pGMLP000589 | human CA11 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002877 | mouse Car11 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002877 | mouse Car11 Lentivirus particle |
Target information
| Target ID | GM-SE0728 |
| Target Name | CA11 |
| Gene ID | 770,12348,308588,718066,484400,101081097,326334,100054121 |
| Gene Symbol and Synonyms | CA-RP,CA-RP II,CA-XI,CA11,CAR-XI,Car11,CARP-2,CARPX1 |
| Uniprot Accession | O75493,Q866X7 |
| Uniprot Entry Name | CAH11_HUMAN,CAH11_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000063180 |
| Target Classification | N/A |
The target: CA11, gene name: CA11, also named as CA-RP, CA-RP II, CA-XI, CARP-2, CARPX1. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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