Anti-APOC2/ APO-CII/ APOC-II functional antibody

Anti-APOC2/ APO-CII/ APOC-II functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to APOC2/APOC2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0673-Ab-1/ GM-Tg-hg-SE0673-Ab-2Anti-Human APOC2 monoclonal antibodyHuman
GM-Tg-rg-SE0673-Ab-1/ GM-Tg-rg-SE0673-Ab-2Anti-Rat APOC2 monoclonal antibodyRat
GM-Tg-mg-SE0673-Ab-1/ GM-Tg-mg-SE0673-Ab-2Anti-Mouse APOC2 monoclonal antibodyMouse
GM-Tg-cynog-SE0673-Ab-1/ GM-Tg-cynog-SE0673-Ab-2Anti-Cynomolgus/ Rhesus macaque APOC2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0673-Ab-1/ GM-Tg-felg-SE0673-Ab-2Anti-Feline APOC2 monoclonal antibodyFeline
GM-Tg-cang-SE0673-Ab-1/ GM-Tg-cang-SE0673-Ab-2Anti-Canine APOC2 monoclonal antibodyCanine
GM-Tg-bovg-SE0673-Ab-1/ GM-Tg-bovg-SE0673-Ab-2Anti-Bovine APOC2 monoclonal antibodyBovine
GM-Tg-equg-SE0673-Ab-1/ GM-Tg-equg-SE0673-Ab-2Anti-Equine APOC2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0673-Ab-1/ GM-Tg-hg-SE0673-Ab-2; GM-Tg-rg-SE0673-Ab-1/ GM-Tg-rg-SE0673-Ab-2;
GM-Tg-mg-SE0673-Ab-1/ GM-Tg-mg-SE0673-Ab-2; GM-Tg-cynog-SE0673-Ab-1/ GM-Tg-cynog-SE0673-Ab-2;
GM-Tg-felg-SE0673-Ab-1/ GM-Tg-felg-SE0673-Ab-2; GM-Tg-cang-SE0673-Ab-1/ GM-Tg-cang-SE0673-Ab-2;
GM-Tg-bovg-SE0673-Ab-1/ GM-Tg-bovg-SE0673-Ab-2; GM-Tg-equg-SE0673-Ab-1/ GM-Tg-equg-SE0673-Ab-2
Products NameAnti-APOC2 monoclonal antibody
Formatmab
Target NameAPOC2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-APOC2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0673-Ag-1Recombinant multi-species APOC2/ APO-CII/ APOC-II protein
    ORF Viral VectorvGMLP004009human APOC2 Lentivirus particle
    ORF Viral VectorpGMLP004009human APOC2 Lentivirus plasmid
    ORF Viral VectorvGMLP003380human APOC2 Lentivirus particle
    ORF Viral VectorpGMLP003380human APOC2 Lentivirus plasmid
    ORF Viral VectorpGMLPm000022mouse Apoc2 Lentivirus plasmid
    ORF Viral VectorvGMLPm000022mouse Apoc2 Lentivirus particle


    Target information

    Target IDGM-SE0673
    Target NameAPOC2
    Gene ID344,11813,292697,100499578,442969,101096861,618039,100065532
    Gene Symbol and SynonymsAPO-CII,APOC-II,APOC2,APOC4,APOCII,RGD1560725
    Uniprot AccessionP02655,G3V8D4,P12278,P19034
    Uniprot Entry NameAPOC2_HUMAN,APOC2_RAT,APOC2_CANLF,APOC2_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseMalignant neoplasm of bladder
    Gene EnsemblENSG00000234906
    Target ClassificationN/A

    The target: APOC2, gene name: APOC2, also named as APO-CII, APOC-II. This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.