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Anti-GDF11/ BMP-11/ BMP11 functional antibody
Anti-GDF11/ BMP-11/ BMP11 functional antibody for cell culture, ELISA & in-vivo assay
Go to GDF11/GDF11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0629-Ab-1/ GM-Tg-hg-SE0629-Ab-2 | Anti-Human GDF11 monoclonal antibody | Human |
| GM-Tg-rg-SE0629-Ab-1/ GM-Tg-rg-SE0629-Ab-2 | Anti-Rat GDF11 monoclonal antibody | Rat |
| GM-Tg-mg-SE0629-Ab-1/ GM-Tg-mg-SE0629-Ab-2 | Anti-Mouse GDF11 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0629-Ab-1/ GM-Tg-cynog-SE0629-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GDF11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0629-Ab-1/ GM-Tg-felg-SE0629-Ab-2 | Anti-Feline GDF11 monoclonal antibody | Feline |
| GM-Tg-cang-SE0629-Ab-1/ GM-Tg-cang-SE0629-Ab-2 | Anti-Canine GDF11 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0629-Ab-1/ GM-Tg-bovg-SE0629-Ab-2 | Anti-Bovine GDF11 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0629-Ab-1/ GM-Tg-equg-SE0629-Ab-2 | Anti-Equine GDF11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0629-Ab-1/ GM-Tg-hg-SE0629-Ab-2; GM-Tg-rg-SE0629-Ab-1/ GM-Tg-rg-SE0629-Ab-2; GM-Tg-mg-SE0629-Ab-1/ GM-Tg-mg-SE0629-Ab-2; GM-Tg-cynog-SE0629-Ab-1/ GM-Tg-cynog-SE0629-Ab-2; GM-Tg-felg-SE0629-Ab-1/ GM-Tg-felg-SE0629-Ab-2; GM-Tg-cang-SE0629-Ab-1/ GM-Tg-cang-SE0629-Ab-2; GM-Tg-bovg-SE0629-Ab-1/ GM-Tg-bovg-SE0629-Ab-2; GM-Tg-equg-SE0629-Ab-1/ GM-Tg-equg-SE0629-Ab-2 |
| Products Name | Anti-GDF11 monoclonal antibody |
| Format | mab |
| Target Name | GDF11 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GDF11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-903 | Pre-Made Luspatercept Biosimilar, Fusion Protein targeting GDF11 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BMP-11/BMP11/VHO |
| Target Antigen | GM-Tg-g-SE0629-Ag-1 | Recombinant multi-species GDF11/ BMP-11/ BMP11 protein |
| Cytokine | GM-Tg-g-SE0629-Ag-1 | growth differentiation factor 11 (GDF11) protein |
| ORF Viral Vector | pGMAD000287 | rat Gdf11 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000296 | house mouse Gdf11 AAV plasmid |
| ORF Viral Vector | vGMAD000287 | rat Gdf11 Adenovirus particle |
| ORF Viral Vector | vGMAAV000296 | house mouse Gdf11 AAV particle |
Target information
| Target ID | GM-SE0629 |
| Target Name | GDF11 |
| Gene ID | 10220,14561,29454,707708,606826,101090704,540517,100058832 |
| Gene Symbol and Synonyms | BMP-11,BMP11,GDF11,VHO |
| Uniprot Accession | O95390,Q9Z217 |
| Uniprot Entry Name | GDF11_HUMAN,GDF11_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000135414 |
| Target Classification | N/A |
The target: GDF11, gene name: GDF11, also named as BMP-11, BMP11. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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