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Anti-PTX3/ TNFAIP5/ TSG-14 functional antibody
Anti-PTX3/ TNFAIP5/ TSG-14 functional antibody for cell culture, ELISA & in-vivo assay
Go to PTX3/PTX3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0602-Ab-1/ GM-Tg-hg-SE0602-Ab-2 | Anti-Human PTX3 monoclonal antibody | Human |
| GM-Tg-rg-SE0602-Ab-1/ GM-Tg-rg-SE0602-Ab-2 | Anti-Rat PTX3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0602-Ab-1/ GM-Tg-mg-SE0602-Ab-2 | Anti-Mouse PTX3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0602-Ab-1/ GM-Tg-cynog-SE0602-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTX3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0602-Ab-1/ GM-Tg-felg-SE0602-Ab-2 | Anti-Feline PTX3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0602-Ab-1/ GM-Tg-cang-SE0602-Ab-2 | Anti-Canine PTX3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0602-Ab-1/ GM-Tg-bovg-SE0602-Ab-2 | Anti-Bovine PTX3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0602-Ab-1/ GM-Tg-equg-SE0602-Ab-2 | Anti-Equine PTX3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0602-Ab-1/ GM-Tg-hg-SE0602-Ab-2; GM-Tg-rg-SE0602-Ab-1/ GM-Tg-rg-SE0602-Ab-2; GM-Tg-mg-SE0602-Ab-1/ GM-Tg-mg-SE0602-Ab-2; GM-Tg-cynog-SE0602-Ab-1/ GM-Tg-cynog-SE0602-Ab-2; GM-Tg-felg-SE0602-Ab-1/ GM-Tg-felg-SE0602-Ab-2; GM-Tg-cang-SE0602-Ab-1/ GM-Tg-cang-SE0602-Ab-2; GM-Tg-bovg-SE0602-Ab-1/ GM-Tg-bovg-SE0602-Ab-2; GM-Tg-equg-SE0602-Ab-1/ GM-Tg-equg-SE0602-Ab-2 |
| Products Name | Anti-PTX3 monoclonal antibody |
| Format | mab |
| Target Name | PTX3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTX3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0602-Ag-1 | Recombinant multi-species PTX3/ TNFAIP5/ TSG-14 protein |
| Cytokine | GM-Tg-g-SE0602-Ag-1 | PTX3 (PTX3) protein |
Target information
| Target ID | GM-SE0602 |
| Target Name | PTX3 |
| Gene ID | 5806,19288,689388,704985,100685178,102902276,541148,102149686 |
| Gene Symbol and Synonyms | PTX3,TNFAIP5,TSG-14 |
| Uniprot Accession | P26022,Q0VCG9 |
| Uniprot Entry Name | PTX3_HUMAN,PTX3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Lung Cancer, Sepsis, Henoch-Schonlein Purpura Nephritis |
| Gene Ensembl | ENSG00000163661 |
| Target Classification | N/A |
The target: PTX3, gene name: PTX3, also named as TNFAIP5, TSG-14. This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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