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Anti-TGBR3/ TGFBR3/ BGCAN functional antibody
Anti-TGBR3/ TGFBR3/ BGCAN functional antibody for cell culture, ELISA & in-vivo assay
Go to TGFBR3/TGFBR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0500-Ab-1/ GM-Tg-hg-SE0500-Ab-2 | Anti-Human TGFBR3 monoclonal antibody | Human |
| GM-Tg-rg-SE0500-Ab-1/ GM-Tg-rg-SE0500-Ab-2 | Anti-Rat TGFBR3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0500-Ab-1/ GM-Tg-mg-SE0500-Ab-2 | Anti-Mouse TGFBR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0500-Ab-1/ GM-Tg-cynog-SE0500-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TGFBR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0500-Ab-1/ GM-Tg-felg-SE0500-Ab-2 | Anti-Feline TGFBR3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0500-Ab-1/ GM-Tg-cang-SE0500-Ab-2 | Anti-Canine TGFBR3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0500-Ab-1/ GM-Tg-bovg-SE0500-Ab-2 | Anti-Bovine TGFBR3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0500-Ab-1/ GM-Tg-equg-SE0500-Ab-2 | Anti-Equine TGFBR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0500-Ab-1/ GM-Tg-hg-SE0500-Ab-2; GM-Tg-rg-SE0500-Ab-1/ GM-Tg-rg-SE0500-Ab-2; GM-Tg-mg-SE0500-Ab-1/ GM-Tg-mg-SE0500-Ab-2; GM-Tg-cynog-SE0500-Ab-1/ GM-Tg-cynog-SE0500-Ab-2; GM-Tg-felg-SE0500-Ab-1/ GM-Tg-felg-SE0500-Ab-2; GM-Tg-cang-SE0500-Ab-1/ GM-Tg-cang-SE0500-Ab-2; GM-Tg-bovg-SE0500-Ab-1/ GM-Tg-bovg-SE0500-Ab-2; GM-Tg-equg-SE0500-Ab-1/ GM-Tg-equg-SE0500-Ab-2 |
| Products Name | Anti-TGFBR3 monoclonal antibody |
| Format | mab |
| Target Name | TGFBR3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TGFBR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0500-Ag-1 | Recombinant multi-species TGBR3/ TGFBR3/ BGCAN protein |
| Cytokine | GM-Tg-g-SE0500-Ag-1 | transforming growth factor, beta receptor III (TGFBR3) protein |
| ORF Viral Vector | pGMLP001368 | human TGFBR3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001368 | human TGFBR3 Lentivirus particle |
Target information
| Target ID | GM-SE0500 |
| Target Name | TGFBR3 |
| Gene ID | 7049,21814,29610,705053,490163,101096404,784894,100060435 |
| Gene Symbol and Synonyms | 1110036H20Rik,betaglycan,BGCAN,TBRIII,TGFBR3 |
| Uniprot Accession | Q03167,P26342 |
| Uniprot Entry Name | TGBR3_HUMAN,TGBR3_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000069702 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: TGFBR3, gene name: TGFBR3, also named as BGCAN, betaglycan. This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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