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Anti-SEM3C/ SEMA3C/ SEMAE functional antibody
Anti-SEM3C/ SEMA3C/ SEMAE functional antibody for cell culture, ELISA & in-vivo assay
Go to SEMA3C/SEMA3C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0460-Ab-1/ GM-Tg-hg-SE0460-Ab-2 | Anti-Human SEMA3C monoclonal antibody | Human |
| GM-Tg-rg-SE0460-Ab-1/ GM-Tg-rg-SE0460-Ab-2 | Anti-Rat SEMA3C monoclonal antibody | Rat |
| GM-Tg-mg-SE0460-Ab-1/ GM-Tg-mg-SE0460-Ab-2 | Anti-Mouse SEMA3C monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0460-Ab-1/ GM-Tg-cynog-SE0460-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SEMA3C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0460-Ab-1/ GM-Tg-felg-SE0460-Ab-2 | Anti-Feline SEMA3C monoclonal antibody | Feline |
| GM-Tg-cang-SE0460-Ab-1/ GM-Tg-cang-SE0460-Ab-2 | Anti-Canine SEMA3C monoclonal antibody | Canine |
| GM-Tg-bovg-SE0460-Ab-1/ GM-Tg-bovg-SE0460-Ab-2 | Anti-Bovine SEMA3C monoclonal antibody | Bovine |
| GM-Tg-equg-SE0460-Ab-1/ GM-Tg-equg-SE0460-Ab-2 | Anti-Equine SEMA3C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0460-Ab-1/ GM-Tg-hg-SE0460-Ab-2; GM-Tg-rg-SE0460-Ab-1/ GM-Tg-rg-SE0460-Ab-2; GM-Tg-mg-SE0460-Ab-1/ GM-Tg-mg-SE0460-Ab-2; GM-Tg-cynog-SE0460-Ab-1/ GM-Tg-cynog-SE0460-Ab-2; GM-Tg-felg-SE0460-Ab-1/ GM-Tg-felg-SE0460-Ab-2; GM-Tg-cang-SE0460-Ab-1/ GM-Tg-cang-SE0460-Ab-2; GM-Tg-bovg-SE0460-Ab-1/ GM-Tg-bovg-SE0460-Ab-2; GM-Tg-equg-SE0460-Ab-1/ GM-Tg-equg-SE0460-Ab-2 |
| Products Name | Anti-SEMA3C monoclonal antibody |
| Format | mab |
| Target Name | SEMA3C |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SEMA3C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0460-Ag-1 | Recombinant multi-species SEM3C/ SEMA3C/ SEMAE protein |
| ORF Viral Vector | pGMLPm003871 | mouse Sema3c Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003871 | mouse Sema3c Lentivirus particle |
Target information
| Target ID | GM-SE0460 |
| Target Name | SEMA3C |
| Gene ID | 10512,20348,296787,708633,475930,101094086,512660,100054706 |
| Gene Symbol and Synonyms | 1110036B02Rik,SEMA3C,SEMAE,SemE |
| Uniprot Accession | Q99985,A7MB70 |
| Uniprot Entry Name | SEM3C_HUMAN,SEM3C_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000075223 |
| Target Classification | N/A |
The target: SEMA3C, gene name: SEMA3C, also named as SEMAE, SemE. This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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