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Anti-PCS1N/ PCSK1N/ BigLEN functional antibody
Anti-PCS1N/ PCSK1N/ BigLEN functional antibody for cell culture, ELISA & in-vivo assay
Go to PCSK1N/PCSK1N products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0400-Ab-1/ GM-Tg-hg-SE0400-Ab-2 | Anti-Human PCSK1N monoclonal antibody | Human |
| GM-Tg-rg-SE0400-Ab-1/ GM-Tg-rg-SE0400-Ab-2 | Anti-Rat PCSK1N monoclonal antibody | Rat |
| GM-Tg-mg-SE0400-Ab-1/ GM-Tg-mg-SE0400-Ab-2 | Anti-Mouse PCSK1N monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0400-Ab-1/ GM-Tg-cynog-SE0400-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCSK1N monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0400-Ab-1/ GM-Tg-felg-SE0400-Ab-2 | Anti-Feline PCSK1N monoclonal antibody | Feline |
| GM-Tg-cang-SE0400-Ab-1/ GM-Tg-cang-SE0400-Ab-2 | Anti-Canine PCSK1N monoclonal antibody | Canine |
| GM-Tg-bovg-SE0400-Ab-1/ GM-Tg-bovg-SE0400-Ab-2 | Anti-Bovine PCSK1N monoclonal antibody | Bovine |
| GM-Tg-equg-SE0400-Ab-1/ GM-Tg-equg-SE0400-Ab-2 | Anti-Equine PCSK1N monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0400-Ab-1/ GM-Tg-hg-SE0400-Ab-2; GM-Tg-rg-SE0400-Ab-1/ GM-Tg-rg-SE0400-Ab-2; GM-Tg-mg-SE0400-Ab-1/ GM-Tg-mg-SE0400-Ab-2; GM-Tg-cynog-SE0400-Ab-1/ GM-Tg-cynog-SE0400-Ab-2; GM-Tg-felg-SE0400-Ab-1/ GM-Tg-felg-SE0400-Ab-2; GM-Tg-cang-SE0400-Ab-1/ GM-Tg-cang-SE0400-Ab-2; GM-Tg-bovg-SE0400-Ab-1/ GM-Tg-bovg-SE0400-Ab-2; GM-Tg-equg-SE0400-Ab-1/ GM-Tg-equg-SE0400-Ab-2 |
| Products Name | Anti-PCSK1N monoclonal antibody |
| Format | mab |
| Target Name | PCSK1N |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCSK1N benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0400-Ag-1 | Recombinant multi-species PCS1N/ PCSK1N/ BigLEN protein |
| ORF Viral Vector | pGMLPm004643 | mouse Pcsk1n Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004643 | mouse Pcsk1n Lentivirus particle |
Target information
| Target ID | GM-SE0400 |
| Target Name | PCSK1N |
| Gene ID | 27344,30052,246333,714789,491870,101096704,513603,111771499 |
| Gene Symbol and Synonyms | BigLEN,bLEN,KEP,lLEN,Pan3,PCSK1N,PEN,PEN19,PEN20,PROSAAS,SAAS,SAASCT,SCG8,SgVIII |
| Uniprot Accession | Q9UHG2,Q9QXU9 |
| Uniprot Entry Name | PCS1N_HUMAN,PCS1N_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000102109 |
| Target Classification | N/A |
The target: PCSK1N, gene name: PCSK1N, also named as BigLEN, PEN, PROSAAS, SAAS, SCG8, SgVIII. The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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