- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PCDGB/ PCDHGA11/ PCDH-GAMMA-A11 functional antibody
Anti-PCDGB/ PCDHGA11/ PCDH-GAMMA-A11 functional antibody for cell culture, ELISA & in-vivo assay
Go to PCDHGA11/PCDHGA11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0399-Ab-1/ GM-Tg-hg-SE0399-Ab-2 | Anti-Human PCDHGA11 monoclonal antibody | Human |
| GM-Tg-rg-SE0399-Ab-1/ GM-Tg-rg-SE0399-Ab-2 | Anti-Rat PCDHGA11 monoclonal antibody | Rat |
| GM-Tg-mg-SE0399-Ab-1/ GM-Tg-mg-SE0399-Ab-2 | Anti-Mouse PCDHGA11 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0399-Ab-1/ GM-Tg-cynog-SE0399-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDHGA11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0399-Ab-1/ GM-Tg-felg-SE0399-Ab-2 | Anti-Feline PCDHGA11 monoclonal antibody | Feline |
| GM-Tg-cang-SE0399-Ab-1/ GM-Tg-cang-SE0399-Ab-2 | Anti-Canine PCDHGA11 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0399-Ab-1/ GM-Tg-bovg-SE0399-Ab-2 | Anti-Bovine PCDHGA11 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0399-Ab-1/ GM-Tg-equg-SE0399-Ab-2 | Anti-Equine PCDHGA11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0399-Ab-1/ GM-Tg-hg-SE0399-Ab-2; GM-Tg-rg-SE0399-Ab-1/ GM-Tg-rg-SE0399-Ab-2; GM-Tg-mg-SE0399-Ab-1/ GM-Tg-mg-SE0399-Ab-2; GM-Tg-cynog-SE0399-Ab-1/ GM-Tg-cynog-SE0399-Ab-2; GM-Tg-felg-SE0399-Ab-1/ GM-Tg-felg-SE0399-Ab-2; GM-Tg-cang-SE0399-Ab-1/ GM-Tg-cang-SE0399-Ab-2; GM-Tg-bovg-SE0399-Ab-1/ GM-Tg-bovg-SE0399-Ab-2; GM-Tg-equg-SE0399-Ab-1/ GM-Tg-equg-SE0399-Ab-2 |
| Products Name | Anti-PCDHGA11 monoclonal antibody |
| Format | mab |
| Target Name | PCDHGA11 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCDHGA11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0399-Ag-1 | Recombinant multi-species PCDGB/ PCDHGA11/ PCDH-GAMMA-A11 protein |
Target information
| Target ID | GM-SE0399 |
| Target Name | PCDHGA11 |
| Gene ID | 56105,93723,114678926 |
| Gene Symbol and Synonyms | PCDH-GAMMA-A11,PCDHGA11 |
| Uniprot Accession | Q9Y5H2 |
| Uniprot Entry Name | PCDGB_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000253873 |
| Target Classification | N/A |
The target: PCDHGA11, gene name: PCDHGA11, also named as PCDH-GAMMA-A11. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
