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Anti-NRG3/ HRG3/ pro-NRG3 functional antibody
Anti-NRG3/ HRG3/ pro-NRG3 functional antibody for cell culture, ELISA & in-vivo assay
Go to NRG3/NRG3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0375-Ab-1/ GM-Tg-hg-SE0375-Ab-2 | Anti-Human NRG3 monoclonal antibody | Human |
| GM-Tg-rg-SE0375-Ab-1/ GM-Tg-rg-SE0375-Ab-2 | Anti-Rat NRG3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0375-Ab-1/ GM-Tg-mg-SE0375-Ab-2 | Anti-Mouse NRG3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0375-Ab-1/ GM-Tg-cynog-SE0375-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRG3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0375-Ab-1/ GM-Tg-felg-SE0375-Ab-2 | Anti-Feline NRG3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0375-Ab-1/ GM-Tg-cang-SE0375-Ab-2 | Anti-Canine NRG3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0375-Ab-1/ GM-Tg-bovg-SE0375-Ab-2 | Anti-Bovine NRG3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0375-Ab-1/ GM-Tg-equg-SE0375-Ab-2 | Anti-Equine NRG3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0375-Ab-1/ GM-Tg-hg-SE0375-Ab-2; GM-Tg-rg-SE0375-Ab-1/ GM-Tg-rg-SE0375-Ab-2; GM-Tg-mg-SE0375-Ab-1/ GM-Tg-mg-SE0375-Ab-2; GM-Tg-cynog-SE0375-Ab-1/ GM-Tg-cynog-SE0375-Ab-2; GM-Tg-felg-SE0375-Ab-1/ GM-Tg-felg-SE0375-Ab-2; GM-Tg-cang-SE0375-Ab-1/ GM-Tg-cang-SE0375-Ab-2; GM-Tg-bovg-SE0375-Ab-1/ GM-Tg-bovg-SE0375-Ab-2; GM-Tg-equg-SE0375-Ab-1/ GM-Tg-equg-SE0375-Ab-2 |
| Products Name | Anti-NRG3 monoclonal antibody |
| Format | mab |
| Target Name | NRG3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRG3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0375-Ag-1 | Recombinant multi-species NRG3/ HRG3/ pro-NRG3 protein |
| Cytokine | GM-Tg-g-SE0375-Ag-1 | neuregulin 3 (NRG3) protein |
Target information
| Target ID | GM-SE0375 |
| Target Name | NRG3 |
| Gene ID | 10718,18183,498596,699268,479263,101082012,539977,100065480 |
| Gene Symbol and Synonyms | HRG3,NRG3,pro-NRG3,RGD1559678,ska |
| Uniprot Accession | P56975 |
| Uniprot Entry Name | NRG3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000185737 |
| Target Classification | N/A |
The target: NRG3, gene name: NRG3, also named as HRG3, pro-NRG3. This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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