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Anti-P3H1/ GROS1/ LEPRE1 functional antibody
Anti-P3H1/ GROS1/ LEPRE1 functional antibody for cell culture, ELISA & in-vivo assay
Go to P3H1/P3H1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0306-Ab-1/ GM-Tg-hg-SE0306-Ab-2 | Anti-Human P3H1 monoclonal antibody | Human |
| GM-Tg-rg-SE0306-Ab-1/ GM-Tg-rg-SE0306-Ab-2 | Anti-Rat P3H1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0306-Ab-1/ GM-Tg-mg-SE0306-Ab-2 | Anti-Mouse P3H1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0306-Ab-1/ GM-Tg-cynog-SE0306-Ab-2 | Anti-Cynomolgus/ Rhesus macaque P3H1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0306-Ab-1/ GM-Tg-felg-SE0306-Ab-2 | Anti-Feline P3H1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0306-Ab-1/ GM-Tg-cang-SE0306-Ab-2 | Anti-Canine P3H1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0306-Ab-1/ GM-Tg-bovg-SE0306-Ab-2 | Anti-Bovine P3H1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0306-Ab-1/ GM-Tg-equg-SE0306-Ab-2 | Anti-Equine P3H1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0306-Ab-1/ GM-Tg-hg-SE0306-Ab-2; GM-Tg-rg-SE0306-Ab-1/ GM-Tg-rg-SE0306-Ab-2; GM-Tg-mg-SE0306-Ab-1/ GM-Tg-mg-SE0306-Ab-2; GM-Tg-cynog-SE0306-Ab-1/ GM-Tg-cynog-SE0306-Ab-2; GM-Tg-felg-SE0306-Ab-1/ GM-Tg-felg-SE0306-Ab-2; GM-Tg-cang-SE0306-Ab-1/ GM-Tg-cang-SE0306-Ab-2; GM-Tg-bovg-SE0306-Ab-1/ GM-Tg-bovg-SE0306-Ab-2; GM-Tg-equg-SE0306-Ab-1/ GM-Tg-equg-SE0306-Ab-2 |
| Products Name | Anti-P3H1 monoclonal antibody |
| Format | mab |
| Target Name | P3H1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-P3H1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0306-Ag-1 | Recombinant multi-species P3H1/ GROS1/ LEPRE1 protein |
| ORF Viral Vector | vGMLP001352 | human NM_001243246humanNM_001243246 Lentivirus particle |
| ORF Viral Vector | pGMLP001352 | human NM_001243246humanNM_001243246 Lentivirus plasmid |
Target information
| Target ID | GM-SE0306 |
| Target Name | P3H1 |
| Gene ID | 64175,56401,114200,697917,606980,101094278,539976,100067315 |
| Gene Symbol and Synonyms | 2410024C15Rik,GROS1,LEPRE1,OI8,P3H1 |
| Uniprot Accession | Q32P28,Q9R1J8 |
| Uniprot Entry Name | P3H1_HUMAN,P3H1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000117385 |
| Target Classification | N/A |
The target: P3H1, gene name: P3H1, also named as GROS1, LEPRE1, OI8. This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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