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Anti-CXL14/ CXCL14/ BMAC functional antibody
Anti-CXL14/ CXCL14/ BMAC functional antibody for cell culture, ELISA & in-vivo assay
Go to CXCL14/CXCL14 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0135-Ab-1/ GM-Tg-hg-SE0135-Ab-2 | Anti-Human CXCL14 monoclonal antibody | Human |
| GM-Tg-rg-SE0135-Ab-1/ GM-Tg-rg-SE0135-Ab-2 | Anti-Rat CXCL14 monoclonal antibody | Rat |
| GM-Tg-mg-SE0135-Ab-1/ GM-Tg-mg-SE0135-Ab-2 | Anti-Mouse CXCL14 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0135-Ab-1/ GM-Tg-cynog-SE0135-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCL14 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0135-Ab-1/ GM-Tg-felg-SE0135-Ab-2 | Anti-Feline CXCL14 monoclonal antibody | Feline |
| GM-Tg-cang-SE0135-Ab-1/ GM-Tg-cang-SE0135-Ab-2 | Anti-Canine CXCL14 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0135-Ab-1/ GM-Tg-bovg-SE0135-Ab-2 | Anti-Bovine CXCL14 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0135-Ab-1/ GM-Tg-equg-SE0135-Ab-2 | Anti-Equine CXCL14 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0135-Ab-1/ GM-Tg-hg-SE0135-Ab-2; GM-Tg-rg-SE0135-Ab-1/ GM-Tg-rg-SE0135-Ab-2; GM-Tg-mg-SE0135-Ab-1/ GM-Tg-mg-SE0135-Ab-2; GM-Tg-cynog-SE0135-Ab-1/ GM-Tg-cynog-SE0135-Ab-2; GM-Tg-felg-SE0135-Ab-1/ GM-Tg-felg-SE0135-Ab-2; GM-Tg-cang-SE0135-Ab-1/ GM-Tg-cang-SE0135-Ab-2; GM-Tg-bovg-SE0135-Ab-1/ GM-Tg-bovg-SE0135-Ab-2; GM-Tg-equg-SE0135-Ab-1/ GM-Tg-equg-SE0135-Ab-2 |
| Products Name | Anti-CXCL14 monoclonal antibody |
| Format | mab |
| Target Name | CXCL14 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCL14 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0135-Ag-1 | Recombinant multi-species CXL14/ CXCL14/ BMAC protein |
| Cytokine | GM-Tg-g-SE0135-Ag-1 | chemokine (C-X-C motif) ligand 14 (CXCL14) protein |
| ORF Viral Vector | pGMLP000121 | human CXCL14 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000121 | human CXCL14 Lentivirus particle |
| ORF Viral Vector | pGMAAV000350 | house mouse Cxcl14 AAV plasmid |
| ORF Viral Vector | pGMLPm001012 | mouse Cxcl14 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000350 | house mouse Cxcl14 AAV particle |
| ORF Viral Vector | vGMLPm001012 | mouse Cxcl14 Lentivirus particle |
Target information
| Target ID | GM-SE0135 |
| Target Name | CXCL14 |
| Gene ID | 9547,57266,306748,712076,610078,101087962,511771,100072697 |
| Gene Symbol and Synonyms | 1110031L23Rik,1200006I23Rik,BMAC,bolekine,BRAK,CXCL14,KEC,KS1,MIP-2g,MIP2G,MIP2gamma,NJAC,SCYB14 |
| Uniprot Accession | O95715 |
| Uniprot Entry Name | CXL14_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000145824 |
| Target Classification | N/A |
The target: CXCL14, gene name: CXCL14, also named as BMAC, BRAK, KEC, KS1, MIP-2g, MIP2G, NJAC, SCYB14. This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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