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Anti-CKLF/ C321/ CKLF2 functional antibody
Anti-CKLF/ C321/ CKLF2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CKLF/CKLF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0092-Ab-1/ GM-Tg-hg-SE0092-Ab-2 | Anti-Human CKLF monoclonal antibody | Human |
| GM-Tg-rg-SE0092-Ab-1/ GM-Tg-rg-SE0092-Ab-2 | Anti-Rat CKLF monoclonal antibody | Rat |
| GM-Tg-mg-SE0092-Ab-1/ GM-Tg-mg-SE0092-Ab-2 | Anti-Mouse CKLF monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0092-Ab-1/ GM-Tg-cynog-SE0092-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CKLF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0092-Ab-1/ GM-Tg-felg-SE0092-Ab-2 | Anti-Feline CKLF monoclonal antibody | Feline |
| GM-Tg-cang-SE0092-Ab-1/ GM-Tg-cang-SE0092-Ab-2 | Anti-Canine CKLF monoclonal antibody | Canine |
| GM-Tg-bovg-SE0092-Ab-1/ GM-Tg-bovg-SE0092-Ab-2 | Anti-Bovine CKLF monoclonal antibody | Bovine |
| GM-Tg-equg-SE0092-Ab-1/ GM-Tg-equg-SE0092-Ab-2 | Anti-Equine CKLF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0092-Ab-1/ GM-Tg-hg-SE0092-Ab-2; GM-Tg-rg-SE0092-Ab-1/ GM-Tg-rg-SE0092-Ab-2; GM-Tg-mg-SE0092-Ab-1/ GM-Tg-mg-SE0092-Ab-2; GM-Tg-cynog-SE0092-Ab-1/ GM-Tg-cynog-SE0092-Ab-2; GM-Tg-felg-SE0092-Ab-1/ GM-Tg-felg-SE0092-Ab-2; GM-Tg-cang-SE0092-Ab-1/ GM-Tg-cang-SE0092-Ab-2; GM-Tg-bovg-SE0092-Ab-1/ GM-Tg-bovg-SE0092-Ab-2; GM-Tg-equg-SE0092-Ab-1/ GM-Tg-equg-SE0092-Ab-2 |
| Products Name | Anti-CKLF monoclonal antibody |
| Format | mab |
| Target Name | CKLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CKLF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0092-Ag-1 | Recombinant multi-species CKLF/ C321/ CKLF2 protein |
| ORF Viral Vector | pGMLP000340 | human CKLF Lentivirus plasmid |
| ORF Viral Vector | vGMLV000747 | human CKLF Lentivirus particle |
| ORF Viral Vector | vGMLP000340 | human CKLF Lentivirus particle |
| ORF Viral Vector | pGMLV000747 | human CKLF Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000706 | mouse Cklf Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000706 | mouse Cklf Lentivirus particle |
Target information
| Target ID | GM-SE0092 |
| Target Name | CKLF |
| Gene ID | 51192,245978 |
| Gene Symbol and Synonyms | C32,CKLF,CKLF1,CKLF2,CKLF3,CKLF4,HSPC224,UCK-1 |
| Uniprot Accession | Q9UBR5,Q9JK79 |
| Uniprot Entry Name | CKLF_HUMAN,CKLF_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000217555 |
| Target Classification | N/A |
The target: CKLF, gene name: CKLF, also named as C321, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1, CKLF. The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CM™1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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