Anti-TCR alpha-beta (abT) monoclonal antibody

Anti-TCR alpha-beta (abT) antibody for FACS & in-vivo assay


Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-MP2610-Ab-1/ GM-Tg-hg-MP2610-Ab-2 Anti-Human TCR alpha-beta (abT) monoclonal antibody Human
GM-Tg-hg-MP2610-Ab-3/ GM-Tg-hg-MP2610-Ab-4 Anti-Human TCR alpha-beta (abT) monoclonal antibody Human
GM-Tg-rg-MP2610-Ab-1/ GM-Tg-rg-MP2610-Ab-2 Anti-Rat TCR alpha-beta (abT) monoclonal antibody Rat
GM-Tg-mg-MP2610-Ab-1/ GM-Tg-mg-MP2610-Ab-2 Anti-Mouse TCR alpha-beta (abT) monoclonal antibody Mouse
GM-Tg-cynog-MP2610-Ab-1/ GM-Tg-cynog-MP2610-Ab-2 Anti-Cynomolgus/ Rhesus macaque TCR alpha-beta (abT) monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-MP2610-Ab-1/ GM-Tg-felg-MP2610-Ab-2 Anti-Feline TCR alpha-beta (abT) monoclonal antibody Feline
GM-Tg-cang-MP2610-Ab-1/ GM-Tg-cang-MP2610-Ab-2 Anti-Canine TCR alpha-beta (abT) monoclonal antibody Canine
GM-Tg-bovg-MP2610-Ab-1/ GM-Tg-bovg-MP2610-Ab-2 Anti-Bovine TCR alpha-beta (abT) monoclonal antibody Bovine
GM-Tg-equg-MP2610-Ab-1/ GM-Tg-equg-MP2610-Ab-2 Anti-Equine TCR alpha-beta (abT) monoclonal antibody Equine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-MP2610-Ab-1/ GM-Tg-hg-MP2610-Ab-2; GM-Tg-hg-MP2610-Ab-3/ GM-Tg-hg-MP2610-Ab-4; GM-Tg-rg-MP2610-Ab-1/ GM-Tg-rg-MP2610-Ab-2;
GM-Tg-mg-MP2610-Ab-1/ GM-Tg-mg-MP2610-Ab-2; GM-Tg-cynog-MP2610-Ab-1/ GM-Tg-cynog-MP2610-Ab-2;
GM-Tg-felg-MP2610-Ab-1/ GM-Tg-felg-MP2610-Ab-2; GM-Tg-cang-MP2610-Ab-1/ GM-Tg-cang-MP2610-Ab-2;
GM-Tg-bovg-MP2610-Ab-1/ GM-Tg-bovg-MP2610-Ab-2; GM-Tg-equg-MP2610-Ab-1/ GM-Tg-equg-MP2610-Ab-2
Products Name Anti-TCR alpha-beta (abT) monoclonal antibody
Format mab
Target Name TCR alpha-beta (abT)
Protein Sub-location Transmembrane Protein
Category of antibody FACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species) Mouse/Human
CH1+2+3 Isotype
(Receptor identification)		 IgG
Type of Light Chain (VD-LC) N/A
Expression platform Mammalian Expression
Bioactivity validation Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Tag Fc
Products description Pre-made anti-TCR alpha-beta (abT) benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Target information

    Target ID GM-MP2610
    Target Name TCR alpha-beta (abT)
    Gene ID 6955 (TRAC), 6957 (TRBC)
    Gene Symbol and Synonyms TCR alpha-beta (abT), T-cell receptor αβ heterodimer, CD3ε/γ/δ/ζ complex partner, TCR-CD3 signaling complex, MHC-restricted antigen receptor
    Uniprot Accession P01850 (TRBC), Q01851 (TRAC)
    Uniprot Entry Name TCRBC_HUMAN (TRBC), TCRAC_HUMAN (TRAC)
    Protein Sub-location Transmembrane Protein (TCR-CD3 complex)
    Category Therapeutic Target, Immune Checkpoint
    Disease Cancer, Autoimmune Diseases
    Gene Ensembl ENSG00000211671 (TRAC), ENSG00000185899 (TRBC)
    Target Classification T-cell receptor αβ chain, Co-receptor complex

    TCR alpha-beta (abT) is a transmembrane protein complex encoded by the TRAC and TRBC genes. GMab Anti-TCRαβ (clone: αβ/CD3) is a mouse IgG monoclonal antibody targeting the αβ T-cell receptor heterodimer, validated for FACS-based affinity binding assays and immunophenotyping. This antibody may function as a critical reagent in vitro and in vivo for therapeutic antibody discovery against TCRαβ-associated targets, including CD3ε/γ/δ/ζ signaling complexes and MHC-restricted antigen recognition pathways.



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM's Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.