Anti-EPS15/ AF-1P/ AF1P monoclonal antibody

Anti-EPS15/ AF-1P/ AF1P antibody for FACS & in-vivo assay

Target products collectionGo to EPS15/EPS15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2578-Ab-1/ GM-Tg-hg-MP2578-Ab-2Anti-Human EPS15 monoclonal antibodyHuman
GM-Tg-rg-MP2578-Ab-1/ GM-Tg-rg-MP2578-Ab-2Anti-Rat EPS15 monoclonal antibodyRat
GM-Tg-mg-MP2578-Ab-1/ GM-Tg-mg-MP2578-Ab-2Anti-Mouse EPS15 monoclonal antibodyMouse
GM-Tg-cynog-MP2578-Ab-1/ GM-Tg-cynog-MP2578-Ab-2Anti-Cynomolgus/ Rhesus macaque EPS15 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2578-Ab-1/ GM-Tg-felg-MP2578-Ab-2Anti-Feline EPS15 monoclonal antibodyFeline
GM-Tg-cang-MP2578-Ab-1/ GM-Tg-cang-MP2578-Ab-2Anti-Canine EPS15 monoclonal antibodyCanine
GM-Tg-bovg-MP2578-Ab-1/ GM-Tg-bovg-MP2578-Ab-2Anti-Bovine EPS15 monoclonal antibodyBovine
GM-Tg-equg-MP2578-Ab-1/ GM-Tg-equg-MP2578-Ab-2Anti-Equine EPS15 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2578-Ab-1/ GM-Tg-hg-MP2578-Ab-2; GM-Tg-rg-MP2578-Ab-1/ GM-Tg-rg-MP2578-Ab-2;
GM-Tg-mg-MP2578-Ab-1/ GM-Tg-mg-MP2578-Ab-2; GM-Tg-cynog-MP2578-Ab-1/ GM-Tg-cynog-MP2578-Ab-2;
GM-Tg-felg-MP2578-Ab-1/ GM-Tg-felg-MP2578-Ab-2; GM-Tg-cang-MP2578-Ab-1/ GM-Tg-cang-MP2578-Ab-2;
GM-Tg-bovg-MP2578-Ab-1/ GM-Tg-bovg-MP2578-Ab-2; GM-Tg-equg-MP2578-Ab-1/ GM-Tg-equg-MP2578-Ab-2
Products NameAnti-EPS15 monoclonal antibody
Formatmab
Target NameEPS15
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EPS15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species EPS15/ AF-1P/ AF1P VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2578
    Target NameEPS15
    Gene ID2060,13858,313474,714767,475356,101087853,535998,100062532
    Gene Symbol and Synonyms2410112D09Rik,AF-1P,AF1P,EPS15,MLLT5,RGD1307641
    Uniprot AccessionP42566
    Uniprot Entry NameEPS15_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000085832
    Target ClassificationN/A

    The target: EPS15, gene name: EPS15, also named as AF-1P, AF1P, MLLT5. This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.