Anti-I5P1/ INPP5A/ 5PTASE monoclonal antibody

Anti-I5P1/ INPP5A/ 5PTASE antibody for FACS & in-vivo assay

Target products collectionGo to INPP5A/INPP5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2575-Ab-1/ GM-Tg-hg-MP2575-Ab-2Anti-Human INPP5A monoclonal antibodyHuman
GM-Tg-rg-MP2575-Ab-1/ GM-Tg-rg-MP2575-Ab-2Anti-Rat INPP5A monoclonal antibodyRat
GM-Tg-mg-MP2575-Ab-1/ GM-Tg-mg-MP2575-Ab-2Anti-Mouse INPP5A monoclonal antibodyMouse
GM-Tg-cynog-MP2575-Ab-1/ GM-Tg-cynog-MP2575-Ab-2Anti-Cynomolgus/ Rhesus macaque INPP5A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2575-Ab-1/ GM-Tg-felg-MP2575-Ab-2Anti-Feline INPP5A monoclonal antibodyFeline
GM-Tg-cang-MP2575-Ab-1/ GM-Tg-cang-MP2575-Ab-2Anti-Canine INPP5A monoclonal antibodyCanine
GM-Tg-bovg-MP2575-Ab-1/ GM-Tg-bovg-MP2575-Ab-2Anti-Bovine INPP5A monoclonal antibodyBovine
GM-Tg-equg-MP2575-Ab-1/ GM-Tg-equg-MP2575-Ab-2Anti-Equine INPP5A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2575-Ab-1/ GM-Tg-hg-MP2575-Ab-2; GM-Tg-rg-MP2575-Ab-1/ GM-Tg-rg-MP2575-Ab-2;
GM-Tg-mg-MP2575-Ab-1/ GM-Tg-mg-MP2575-Ab-2; GM-Tg-cynog-MP2575-Ab-1/ GM-Tg-cynog-MP2575-Ab-2;
GM-Tg-felg-MP2575-Ab-1/ GM-Tg-felg-MP2575-Ab-2; GM-Tg-cang-MP2575-Ab-1/ GM-Tg-cang-MP2575-Ab-2;
GM-Tg-bovg-MP2575-Ab-1/ GM-Tg-bovg-MP2575-Ab-2; GM-Tg-equg-MP2575-Ab-1/ GM-Tg-equg-MP2575-Ab-2
Products NameAnti-INPP5A monoclonal antibody
Formatmab
Target NameINPP5A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-INPP5A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species I5P1/ INPP5A/ 5PTASE VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2575
    Target NameINPP5A
    Gene ID3632,212111,365382,719508,403937,101083037,615232,100051027
    Gene Symbol and Synonyms5PTASE,INPP5A
    Uniprot AccessionQ14642,D3ZZX1,Q29467
    Uniprot Entry NameI5P1_HUMAN,I5P1_RAT,I5P1_CANLF
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000068383
    Target ClassificationN/A

    The target: INPP5A, gene name: INPP5A, also named as 5PTASE. The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.