Anti-IL1RA/ IL1RN/ DIRA monoclonal antibody

Anti-IL1RA/ IL1RN/ DIRA antibody for FACS & in-vivo assay

Target products collectionGo to IL1RN/IL1RN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2544-Ab-1/ GM-Tg-hg-MP2544-Ab-2Anti-Human IL1RN monoclonal antibodyHuman
GM-Tg-rg-MP2544-Ab-1/ GM-Tg-rg-MP2544-Ab-2Anti-Rat IL1RN monoclonal antibodyRat
GM-Tg-mg-MP2544-Ab-1/ GM-Tg-mg-MP2544-Ab-2Anti-Mouse IL1RN monoclonal antibodyMouse
GM-Tg-cynog-MP2544-Ab-1/ GM-Tg-cynog-MP2544-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1RN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2544-Ab-1/ GM-Tg-felg-MP2544-Ab-2Anti-Feline IL1RN monoclonal antibodyFeline
GM-Tg-cang-MP2544-Ab-1/ GM-Tg-cang-MP2544-Ab-2Anti-Canine IL1RN monoclonal antibodyCanine
GM-Tg-bovg-MP2544-Ab-1/ GM-Tg-bovg-MP2544-Ab-2Anti-Bovine IL1RN monoclonal antibodyBovine
GM-Tg-equg-MP2544-Ab-1/ GM-Tg-equg-MP2544-Ab-2Anti-Equine IL1RN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2544-Ab-1/ GM-Tg-hg-MP2544-Ab-2; GM-Tg-rg-MP2544-Ab-1/ GM-Tg-rg-MP2544-Ab-2;
GM-Tg-mg-MP2544-Ab-1/ GM-Tg-mg-MP2544-Ab-2; GM-Tg-cynog-MP2544-Ab-1/ GM-Tg-cynog-MP2544-Ab-2;
GM-Tg-felg-MP2544-Ab-1/ GM-Tg-felg-MP2544-Ab-2; GM-Tg-cang-MP2544-Ab-1/ GM-Tg-cang-MP2544-Ab-2;
GM-Tg-bovg-MP2544-Ab-1/ GM-Tg-bovg-MP2544-Ab-2; GM-Tg-equg-MP2544-Ab-1/ GM-Tg-equg-MP2544-Ab-2
Products NameAnti-IL1RN monoclonal antibody
Formatmab
Target NameIL1RN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1RN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IL1RA/ IL1RN/ DIRA VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP2544-Ag-1interleukin 1 receptor antagonist (IL1RN) protein
    ORF Viral VectorpGMAP000045Human IL1RN Adenovirus plasmid
    ORF Viral VectorvGMAP000045Human IL1RN Adenovirus particle
    ORF Viral VectorpGMLP000397human IL1RN Lentivirus plasmid
    ORF Viral VectorvGMLP000397human IL1RN Lentivirus particle
    ORF Viral VectorpGMLV000054mouse Il1rn Lentivirus plasmid
    ORF Viral VectorvGMLV000054mouse Il1rn Lentivirus particle


    Target information

    Target IDGM-MP2544
    Target NameIL1RN
    Gene ID3557,16181,60582,701658,281860,100034236
    Gene Symbol and SynonymsDIRA,F630041P17Rik,ICIL-1RA,IL-1ra,IL-1ra3,IL-1RN,IL1F3,IL1RA,IL1RN,IRAP,MVCD4
    Uniprot AccessionP18510,P25086,Q9BEH0,O77482,O18999
    Uniprot Entry NameIL1RA_HUMAN,IL1RA_RAT,IL1RA_CANLF,IL1RA_BOVIN,IL1RA_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000136689
    Target ClassificationTumor-associated antigen (TAA)

    The target: IL1RN, gene name: IL1RN, also named as DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.