Anti-TES/ TESSS-2 monoclonal antibody

Anti-TES/ TESSS-2 antibody for FACS & in-vivo assay

Target products collectionGo to TES/TES products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2352-Ab-1/ GM-Tg-hg-MP2352-Ab-2Anti-Human TES monoclonal antibodyHuman
GM-Tg-rg-MP2352-Ab-1/ GM-Tg-rg-MP2352-Ab-2Anti-Rat TES monoclonal antibodyRat
GM-Tg-mg-MP2352-Ab-1/ GM-Tg-mg-MP2352-Ab-2Anti-Mouse TES monoclonal antibodyMouse
GM-Tg-cynog-MP2352-Ab-1/ GM-Tg-cynog-MP2352-Ab-2Anti-Cynomolgus/ Rhesus macaque TES monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2352-Ab-1/ GM-Tg-felg-MP2352-Ab-2Anti-Feline TES monoclonal antibodyFeline
GM-Tg-cang-MP2352-Ab-1/ GM-Tg-cang-MP2352-Ab-2Anti-Canine TES monoclonal antibodyCanine
GM-Tg-bovg-MP2352-Ab-1/ GM-Tg-bovg-MP2352-Ab-2Anti-Bovine TES monoclonal antibodyBovine
GM-Tg-equg-MP2352-Ab-1/ GM-Tg-equg-MP2352-Ab-2Anti-Equine TES monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2352-Ab-1/ GM-Tg-hg-MP2352-Ab-2; GM-Tg-rg-MP2352-Ab-1/ GM-Tg-rg-MP2352-Ab-2;
GM-Tg-mg-MP2352-Ab-1/ GM-Tg-mg-MP2352-Ab-2; GM-Tg-cynog-MP2352-Ab-1/ GM-Tg-cynog-MP2352-Ab-2;
GM-Tg-felg-MP2352-Ab-1/ GM-Tg-felg-MP2352-Ab-2; GM-Tg-cang-MP2352-Ab-1/ GM-Tg-cang-MP2352-Ab-2;
GM-Tg-bovg-MP2352-Ab-1/ GM-Tg-bovg-MP2352-Ab-2; GM-Tg-equg-MP2352-Ab-1/ GM-Tg-equg-MP2352-Ab-2
Products NameAnti-TES monoclonal antibody
Formatmab
Target NameTES
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TES benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TES/ TESSS-2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP005111human TES Lentivirus particle
    ORF Viral VectorvGMLV000115human TES Lentivirus particle
    ORF Viral VectorpGMLP005111human TES Lentivirus plasmid
    ORF Viral VectorpGMLV000115human TES Lentivirus plasmid
    ORF Viral VectorpGMLPm003964mouse Tes Lentivirus plasmid
    ORF Viral VectorvGMLPm003964mouse Tes Lentivirus particle


    Target information

    Target IDGM-MP2352
    Target NameTES
    Gene ID26136,21753,500040,706879,475293,100137197,534965,100071093
    Gene Symbol and SynonymsD6Ertd352e,TES,Tes1,Tes2,TESS,TESS-2,Testin,testin2
    Uniprot AccessionQ9UGI8,Q2LAP6,A0M8U6,A0M8S5,Q2YDE9,Q2QLB2
    Uniprot Entry NameTES_HUMAN,TES_RAT,TES_FELCA,TES_CANLF,TES_BOVIN,TES_HORSE
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000135269
    Target ClassificationTumor-associated antigen (TAA)

    The target: TES, gene name: TES, also named as TESSS-2, TES. Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.