Anti-SEPT2/ DIFF6/ NEDD-5 monoclonal antibody

Anti-SEPT2/ DIFF6/ NEDD-5 antibody for FACS & in-vivo assay

Target products collectionGo to SEPT2/SEPT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2322-Ab-1/ GM-Tg-hg-MP2322-Ab-2Anti-Human SEPT2 monoclonal antibodyHuman
GM-Tg-rg-MP2322-Ab-1/ GM-Tg-rg-MP2322-Ab-2Anti-Rat SEPT2 monoclonal antibodyRat
GM-Tg-mg-MP2322-Ab-1/ GM-Tg-mg-MP2322-Ab-2Anti-Mouse SEPT2 monoclonal antibodyMouse
GM-Tg-cynog-MP2322-Ab-1/ GM-Tg-cynog-MP2322-Ab-2Anti-Cynomolgus/ Rhesus macaque SEPT2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2322-Ab-1/ GM-Tg-felg-MP2322-Ab-2Anti-Feline SEPT2 monoclonal antibodyFeline
GM-Tg-cang-MP2322-Ab-1/ GM-Tg-cang-MP2322-Ab-2Anti-Canine SEPT2 monoclonal antibodyCanine
GM-Tg-bovg-MP2322-Ab-1/ GM-Tg-bovg-MP2322-Ab-2Anti-Bovine SEPT2 monoclonal antibodyBovine
GM-Tg-equg-MP2322-Ab-1/ GM-Tg-equg-MP2322-Ab-2Anti-Equine SEPT2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2322-Ab-1/ GM-Tg-hg-MP2322-Ab-2; GM-Tg-rg-MP2322-Ab-1/ GM-Tg-rg-MP2322-Ab-2;
GM-Tg-mg-MP2322-Ab-1/ GM-Tg-mg-MP2322-Ab-2; GM-Tg-cynog-MP2322-Ab-1/ GM-Tg-cynog-MP2322-Ab-2;
GM-Tg-felg-MP2322-Ab-1/ GM-Tg-felg-MP2322-Ab-2; GM-Tg-cang-MP2322-Ab-1/ GM-Tg-cang-MP2322-Ab-2;
GM-Tg-bovg-MP2322-Ab-1/ GM-Tg-bovg-MP2322-Ab-2; GM-Tg-equg-MP2322-Ab-1/ GM-Tg-equg-MP2322-Ab-2
Products NameAnti-SEPT2 monoclonal antibody
Formatmab
Target NameSEPT2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SEPT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SEPT2/ DIFF6/ NEDD-5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2322
    Target NameSEPT2
    Gene ID4735,18000,117515,717682,487886,101090886,511612,100057933
    Gene Symbol and SynonymsDIFF6,hNedd5,mKIAA0158,NEDD-5,NEDD5,Pnutl3,SEPT2,septin-2,SEPTIN2,Vesp11
    Uniprot AccessionQ15019,Q91Y81,Q2NKY7
    Uniprot Entry NameSEPT2_HUMAN,SEPT2_RAT,SEPT2_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000168385
    Target ClassificationN/A

    The target: SEPT2, gene name: SEPT2, also named as DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5. Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of exocytosis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.