Anti-SAMH1/ SAMHD1/ CHBL2 monoclonal antibody
Anti-SAMH1/ SAMHD1/ CHBL2 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-MP2316-Ab-1/ GM-Tg-hg-MP2316-Ab-2 | Anti-Human SAMHD1 monoclonal antibody | Human |
GM-Tg-rg-MP2316-Ab-1/ GM-Tg-rg-MP2316-Ab-2 | Anti-Rat SAMHD1 monoclonal antibody | Rat |
GM-Tg-mg-MP2316-Ab-1/ GM-Tg-mg-MP2316-Ab-2 | Anti-Mouse SAMHD1 monoclonal antibody | Mouse |
GM-Tg-cynog-MP2316-Ab-1/ GM-Tg-cynog-MP2316-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SAMHD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-MP2316-Ab-1/ GM-Tg-felg-MP2316-Ab-2 | Anti-Feline SAMHD1 monoclonal antibody | Feline |
GM-Tg-cang-MP2316-Ab-1/ GM-Tg-cang-MP2316-Ab-2 | Anti-Canine SAMHD1 monoclonal antibody | Canine |
GM-Tg-bovg-MP2316-Ab-1/ GM-Tg-bovg-MP2316-Ab-2 | Anti-Bovine SAMHD1 monoclonal antibody | Bovine |
GM-Tg-equg-MP2316-Ab-1/ GM-Tg-equg-MP2316-Ab-2 | Anti-Equine SAMHD1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-MP2316-Ab-1/ GM-Tg-hg-MP2316-Ab-2; GM-Tg-rg-MP2316-Ab-1/ GM-Tg-rg-MP2316-Ab-2; GM-Tg-mg-MP2316-Ab-1/ GM-Tg-mg-MP2316-Ab-2; GM-Tg-cynog-MP2316-Ab-1/ GM-Tg-cynog-MP2316-Ab-2; GM-Tg-felg-MP2316-Ab-1/ GM-Tg-felg-MP2316-Ab-2; GM-Tg-cang-MP2316-Ab-1/ GM-Tg-cang-MP2316-Ab-2; GM-Tg-bovg-MP2316-Ab-1/ GM-Tg-bovg-MP2316-Ab-2; GM-Tg-equg-MP2316-Ab-1/ GM-Tg-equg-MP2316-Ab-2 |
Products Name | Anti-SAMHD1 monoclonal antibody |
Format | mab |
Target Name | SAMHD1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SAMHD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SAMH1/ SAMHD1/ CHBL2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm005221 | mouse Samhd1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm005221 | mouse Samhd1 Lentivirus particle |
Target information
Target ID | GM-MP2316 |
Target Name | SAMHD1 |
Gene ID | 25939,56045,311580,709060,485862,101095890,524683,100069764 |
Gene Symbol and Synonyms | CHBL2,DCIP,E330031J07Rik,HDDC1,hSAMHD1,Mg11,MOP-5,mSAMHD1,SAMHD1,SBBI88 |
Uniprot Accession | Q9Y3Z3,Q0VCA5 |
Uniprot Entry Name | SAMH1_HUMAN,SAMH1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000101347 |
Target Classification | N/A |
The target: SAMHD1, gene name: SAMHD1, also named as CHBL2, DCIP, HDDC1, MOP-5, SBBI88, hSAMHD1. This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.