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Anti-NCS1/ FLUP/ FREQ monoclonal antibody
Anti-NCS1/ FLUP/ FREQ antibody for FACS & in-vivo assay
Go to NCS1/NCS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2213-Ab-1/ GM-Tg-hg-MP2213-Ab-2 | Anti-Human NCS1 monoclonal antibody | Human |
| GM-Tg-rg-MP2213-Ab-1/ GM-Tg-rg-MP2213-Ab-2 | Anti-Rat NCS1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2213-Ab-1/ GM-Tg-mg-MP2213-Ab-2 | Anti-Mouse NCS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2213-Ab-1/ GM-Tg-cynog-MP2213-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NCS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2213-Ab-1/ GM-Tg-felg-MP2213-Ab-2 | Anti-Feline NCS1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2213-Ab-1/ GM-Tg-cang-MP2213-Ab-2 | Anti-Canine NCS1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2213-Ab-1/ GM-Tg-bovg-MP2213-Ab-2 | Anti-Bovine NCS1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2213-Ab-1/ GM-Tg-equg-MP2213-Ab-2 | Anti-Equine NCS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2213-Ab-1/ GM-Tg-hg-MP2213-Ab-2; GM-Tg-rg-MP2213-Ab-1/ GM-Tg-rg-MP2213-Ab-2; GM-Tg-mg-MP2213-Ab-1/ GM-Tg-mg-MP2213-Ab-2; GM-Tg-cynog-MP2213-Ab-1/ GM-Tg-cynog-MP2213-Ab-2; GM-Tg-felg-MP2213-Ab-1/ GM-Tg-felg-MP2213-Ab-2; GM-Tg-cang-MP2213-Ab-1/ GM-Tg-cang-MP2213-Ab-2; GM-Tg-bovg-MP2213-Ab-1/ GM-Tg-bovg-MP2213-Ab-2; GM-Tg-equg-MP2213-Ab-1/ GM-Tg-equg-MP2213-Ab-2 |
| Products Name | Anti-NCS1 monoclonal antibody |
| Format | mab |
| Target Name | NCS1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NCS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NCS1/ FLUP/ FREQ VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001257 | human NCS1 Lentivirus particle |
| ORF Viral Vector | pGMLP001257 | human NCS1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000747 | mouse Ncs1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000747 | mouse Ncs1 Lentivirus particle |
Target information
| Target ID | GM-MP2213 |
| Target Name | NCS1 |
| Gene ID | 23413,14299,65153,722507,491294,101097027,526544,100069825 |
| Gene Symbol and Synonyms | 9430075O15Rik,A730032G13Rik,FLUP,FREQ,Mfreq,NCS-1,NCS1 |
| Uniprot Accession | P62166,P62168,Q2V8Y7 |
| Uniprot Entry Name | NCS1_HUMAN,NCS1_RAT,NCS1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000107130 |
| Target Classification | N/A |
The target: NCS1, gene name: NCS1, also named as FLUP, FREQ. This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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