Anti-MAOX/ ME1/ HUMNDME monoclonal antibody
Anti-MAOX/ ME1/ HUMNDME antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-MP2197-Ab-1/ GM-Tg-hg-MP2197-Ab-2 | Anti-Human ME1 monoclonal antibody | Human |
GM-Tg-rg-MP2197-Ab-1/ GM-Tg-rg-MP2197-Ab-2 | Anti-Rat ME1 monoclonal antibody | Rat |
GM-Tg-mg-MP2197-Ab-1/ GM-Tg-mg-MP2197-Ab-2 | Anti-Mouse ME1 monoclonal antibody | Mouse |
GM-Tg-cynog-MP2197-Ab-1/ GM-Tg-cynog-MP2197-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ME1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-MP2197-Ab-1/ GM-Tg-felg-MP2197-Ab-2 | Anti-Feline ME1 monoclonal antibody | Feline |
GM-Tg-cang-MP2197-Ab-1/ GM-Tg-cang-MP2197-Ab-2 | Anti-Canine ME1 monoclonal antibody | Canine |
GM-Tg-bovg-MP2197-Ab-1/ GM-Tg-bovg-MP2197-Ab-2 | Anti-Bovine ME1 monoclonal antibody | Bovine |
GM-Tg-equg-MP2197-Ab-1/ GM-Tg-equg-MP2197-Ab-2 | Anti-Equine ME1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-MP2197-Ab-1/ GM-Tg-hg-MP2197-Ab-2; GM-Tg-rg-MP2197-Ab-1/ GM-Tg-rg-MP2197-Ab-2; GM-Tg-mg-MP2197-Ab-1/ GM-Tg-mg-MP2197-Ab-2; GM-Tg-cynog-MP2197-Ab-1/ GM-Tg-cynog-MP2197-Ab-2; GM-Tg-felg-MP2197-Ab-1/ GM-Tg-felg-MP2197-Ab-2; GM-Tg-cang-MP2197-Ab-1/ GM-Tg-cang-MP2197-Ab-2; GM-Tg-bovg-MP2197-Ab-1/ GM-Tg-bovg-MP2197-Ab-2; GM-Tg-equg-MP2197-Ab-1/ GM-Tg-equg-MP2197-Ab-2 |
Products Name | Anti-ME1 monoclonal antibody |
Format | mab |
Target Name | ME1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ME1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species MAOX/ ME1/ HUMNDME VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLV000291 | human ME1 Lentivirus particle |
ORF Viral Vector | pGMLV000291 | human ME1 Lentivirus plasmid |
ORF Viral Vector | pGMLPm002742 | mouse Me1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002742 | mouse Me1 Lentivirus particle |
Target information
Target ID | GM-MP2197 |
Target Name | ME1 |
Gene ID | 4199,17436,24552,694739,403709,101082153,540985,100070127 |
Gene Symbol and Synonyms | D9Ertd267e,HUMNDME,Mdh-1,ME1,MES,Mod-1,Mod1 |
Uniprot Accession | P48163,P13697 |
Uniprot Entry Name | MAOX_HUMAN,MAOX_RAT |
Protein Sub-location | Transmembrane Protein |
Category | |
Disease | Prostate Cancer |
Gene Ensembl | ENSG00000065833 |
Target Classification | N/A |
The target: ME1, gene name: ME1, also named as HUMNDME, MES. This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.