Anti-MARK2/ EMK-1/ EMK1 monoclonal antibody

Anti-MARK2/ EMK-1/ EMK1 antibody for FACS & in-vivo assay

Target products collectionGo to MARK2/MARK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2195-Ab-1/ GM-Tg-hg-MP2195-Ab-2Anti-Human MARK2 monoclonal antibodyHuman
GM-Tg-rg-MP2195-Ab-1/ GM-Tg-rg-MP2195-Ab-2Anti-Rat MARK2 monoclonal antibodyRat
GM-Tg-mg-MP2195-Ab-1/ GM-Tg-mg-MP2195-Ab-2Anti-Mouse MARK2 monoclonal antibodyMouse
GM-Tg-cynog-MP2195-Ab-1/ GM-Tg-cynog-MP2195-Ab-2Anti-Cynomolgus/ Rhesus macaque MARK2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2195-Ab-1/ GM-Tg-felg-MP2195-Ab-2Anti-Feline MARK2 monoclonal antibodyFeline
GM-Tg-cang-MP2195-Ab-1/ GM-Tg-cang-MP2195-Ab-2Anti-Canine MARK2 monoclonal antibodyCanine
GM-Tg-bovg-MP2195-Ab-1/ GM-Tg-bovg-MP2195-Ab-2Anti-Bovine MARK2 monoclonal antibodyBovine
GM-Tg-equg-MP2195-Ab-1/ GM-Tg-equg-MP2195-Ab-2Anti-Equine MARK2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2195-Ab-1/ GM-Tg-hg-MP2195-Ab-2; GM-Tg-rg-MP2195-Ab-1/ GM-Tg-rg-MP2195-Ab-2;
GM-Tg-mg-MP2195-Ab-1/ GM-Tg-mg-MP2195-Ab-2; GM-Tg-cynog-MP2195-Ab-1/ GM-Tg-cynog-MP2195-Ab-2;
GM-Tg-felg-MP2195-Ab-1/ GM-Tg-felg-MP2195-Ab-2; GM-Tg-cang-MP2195-Ab-1/ GM-Tg-cang-MP2195-Ab-2;
GM-Tg-bovg-MP2195-Ab-1/ GM-Tg-bovg-MP2195-Ab-2; GM-Tg-equg-MP2195-Ab-1/ GM-Tg-equg-MP2195-Ab-2
Products NameAnti-MARK2 monoclonal antibody
Formatmab
Target NameMARK2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MARK2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MARK2/ EMK-1/ EMK1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2195
    Target NameMARK2
    Gene ID2011,13728,60328,718065,483769,101095375,535197,100049882
    Gene Symbol and SynonymsEmk,EMK-1,EMK1,MARK2,PAR-1,Par-1b,Par1b
    Uniprot AccessionQ7KZI7,O08679
    Uniprot Entry NameMARK2_HUMAN,MARK2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000072518
    Target ClassificationKinase

    The target: MARK2, gene name: MARK2, also named as EMK-1, EMK1, PAR-1, Par-1b, Par1b. This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.