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Anti-PLSL/ LCP1/ CP64 monoclonal antibody
Anti-PLSL/ LCP1/ CP64 antibody for FACS & in-vivo assay
Go to LCP1/LCP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2182-Ab-1/ GM-Tg-hg-MP2182-Ab-2 | Anti-Human LCP1 monoclonal antibody | Human |
| GM-Tg-rg-MP2182-Ab-1/ GM-Tg-rg-MP2182-Ab-2 | Anti-Rat LCP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2182-Ab-1/ GM-Tg-mg-MP2182-Ab-2 | Anti-Mouse LCP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2182-Ab-1/ GM-Tg-cynog-MP2182-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LCP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2182-Ab-1/ GM-Tg-felg-MP2182-Ab-2 | Anti-Feline LCP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2182-Ab-1/ GM-Tg-cang-MP2182-Ab-2 | Anti-Canine LCP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2182-Ab-1/ GM-Tg-bovg-MP2182-Ab-2 | Anti-Bovine LCP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2182-Ab-1/ GM-Tg-equg-MP2182-Ab-2 | Anti-Equine LCP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2182-Ab-1/ GM-Tg-hg-MP2182-Ab-2; GM-Tg-rg-MP2182-Ab-1/ GM-Tg-rg-MP2182-Ab-2; GM-Tg-mg-MP2182-Ab-1/ GM-Tg-mg-MP2182-Ab-2; GM-Tg-cynog-MP2182-Ab-1/ GM-Tg-cynog-MP2182-Ab-2; GM-Tg-felg-MP2182-Ab-1/ GM-Tg-felg-MP2182-Ab-2; GM-Tg-cang-MP2182-Ab-1/ GM-Tg-cang-MP2182-Ab-2; GM-Tg-bovg-MP2182-Ab-1/ GM-Tg-bovg-MP2182-Ab-2; GM-Tg-equg-MP2182-Ab-1/ GM-Tg-equg-MP2182-Ab-2 |
| Products Name | Anti-LCP1 monoclonal antibody |
| Format | mab |
| Target Name | LCP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LCP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PLSL/ LCP1/ CP64 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001085 | human LCP1 Lentivirus particle |
| ORF Viral Vector | pGMLP001085 | human LCP1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001611 | mouse Lcp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001611 | mouse Lcp1 Lentivirus particle |
Target information
| Target ID | GM-MP2182 |
| Target Name | LCP1 |
| Gene ID | 3936,18826,306071,703429,476921,101081857,540990,100050663 |
| Gene Symbol and Synonyms | CP64,D14Ertd310e,HEL-S-37,L-PLASTIN,LC64P,LCP-1,LCP1,LPL,plastin-2,PLS2,pp65 |
| Uniprot Accession | P13796 |
| Uniprot Entry Name | PLSL_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000136167 |
| Target Classification | N/A |
The target: LCP1, gene name: LCP1, also named as CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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