Anti-KTNB1/ KATNB1/ KAT monoclonal antibody

Anti-KTNB1/ KATNB1/ KAT antibody for FACS & in-vivo assay

Target products collectionGo to KATNB1/KATNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2172-Ab-1/ GM-Tg-hg-MP2172-Ab-2Anti-Human KATNB1 monoclonal antibodyHuman
GM-Tg-rg-MP2172-Ab-1/ GM-Tg-rg-MP2172-Ab-2Anti-Rat KATNB1 monoclonal antibodyRat
GM-Tg-mg-MP2172-Ab-1/ GM-Tg-mg-MP2172-Ab-2Anti-Mouse KATNB1 monoclonal antibodyMouse
GM-Tg-cynog-MP2172-Ab-1/ GM-Tg-cynog-MP2172-Ab-2Anti-Cynomolgus/ Rhesus macaque KATNB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2172-Ab-1/ GM-Tg-felg-MP2172-Ab-2Anti-Feline KATNB1 monoclonal antibodyFeline
GM-Tg-cang-MP2172-Ab-1/ GM-Tg-cang-MP2172-Ab-2Anti-Canine KATNB1 monoclonal antibodyCanine
GM-Tg-bovg-MP2172-Ab-1/ GM-Tg-bovg-MP2172-Ab-2Anti-Bovine KATNB1 monoclonal antibodyBovine
GM-Tg-equg-MP2172-Ab-1/ GM-Tg-equg-MP2172-Ab-2Anti-Equine KATNB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2172-Ab-1/ GM-Tg-hg-MP2172-Ab-2; GM-Tg-rg-MP2172-Ab-1/ GM-Tg-rg-MP2172-Ab-2;
GM-Tg-mg-MP2172-Ab-1/ GM-Tg-mg-MP2172-Ab-2; GM-Tg-cynog-MP2172-Ab-1/ GM-Tg-cynog-MP2172-Ab-2;
GM-Tg-felg-MP2172-Ab-1/ GM-Tg-felg-MP2172-Ab-2; GM-Tg-cang-MP2172-Ab-1/ GM-Tg-cang-MP2172-Ab-2;
GM-Tg-bovg-MP2172-Ab-1/ GM-Tg-bovg-MP2172-Ab-2; GM-Tg-equg-MP2172-Ab-1/ GM-Tg-equg-MP2172-Ab-2
Products NameAnti-KATNB1 monoclonal antibody
Formatmab
Target NameKATNB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KATNB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KTNB1/ KATNB1/ KAT VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2172
    Target NameKATNB1
    Gene ID10300,74187,291852,711862,612852,101086522,508813,100052319
    Gene Symbol and Synonyms2410003J24Rik,KAT,KATNB1,LIS6
    Uniprot AccessionQ9BVA0
    Uniprot Entry NameKTNB1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000140854
    Target ClassificationN/A

    The target: KATNB1, gene name: KATNB1, also named as KAT, LIS6. Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.