Anti-GMIP/ ARHGAP46 monoclonal antibody

Anti-GMIP/ ARHGAP46 antibody for FACS & in-vivo assay

Target products collectionGo to GMIP/GMIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2142-Ab-1/ GM-Tg-hg-MP2142-Ab-2Anti-Human GMIP monoclonal antibodyHuman
GM-Tg-rg-MP2142-Ab-1/ GM-Tg-rg-MP2142-Ab-2Anti-Rat GMIP monoclonal antibodyRat
GM-Tg-mg-MP2142-Ab-1/ GM-Tg-mg-MP2142-Ab-2Anti-Mouse GMIP monoclonal antibodyMouse
GM-Tg-cynog-MP2142-Ab-1/ GM-Tg-cynog-MP2142-Ab-2Anti-Cynomolgus/ Rhesus macaque GMIP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2142-Ab-1/ GM-Tg-felg-MP2142-Ab-2Anti-Feline GMIP monoclonal antibodyFeline
GM-Tg-cang-MP2142-Ab-1/ GM-Tg-cang-MP2142-Ab-2Anti-Canine GMIP monoclonal antibodyCanine
GM-Tg-bovg-MP2142-Ab-1/ GM-Tg-bovg-MP2142-Ab-2Anti-Bovine GMIP monoclonal antibodyBovine
GM-Tg-equg-MP2142-Ab-1/ GM-Tg-equg-MP2142-Ab-2Anti-Equine GMIP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2142-Ab-1/ GM-Tg-hg-MP2142-Ab-2; GM-Tg-rg-MP2142-Ab-1/ GM-Tg-rg-MP2142-Ab-2;
GM-Tg-mg-MP2142-Ab-1/ GM-Tg-mg-MP2142-Ab-2; GM-Tg-cynog-MP2142-Ab-1/ GM-Tg-cynog-MP2142-Ab-2;
GM-Tg-felg-MP2142-Ab-1/ GM-Tg-felg-MP2142-Ab-2; GM-Tg-cang-MP2142-Ab-1/ GM-Tg-cang-MP2142-Ab-2;
GM-Tg-bovg-MP2142-Ab-1/ GM-Tg-bovg-MP2142-Ab-2; GM-Tg-equg-MP2142-Ab-1/ GM-Tg-equg-MP2142-Ab-2
Products NameAnti-GMIP monoclonal antibody
Formatmab
Target NameGMIP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GMIP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GMIP/ ARHGAP46 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2142
    Target NameGMIP
    Gene ID51291,78816,306357,720380,484801,101101198,533029,100069702
    Gene Symbol and Synonyms5031419I10Rik,ARHGAP46,GMIP,RGD1565577
    Uniprot AccessionQ9P107
    Uniprot Entry NameGMIP_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000089639
    Target ClassificationN/A

    The target: GMIP, gene name: GMIP, also named as ARHGAP46. This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.