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Anti-FRS2/ FRS1AA/ FRS2alpha monoclonal antibody
Anti-FRS2/ FRS1AA/ FRS2alpha antibody for FACS & in-vivo assay
Go to FRS2/FRS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2132-Ab-1/ GM-Tg-hg-MP2132-Ab-2 | Anti-Human FRS2 monoclonal antibody | Human |
| GM-Tg-rg-MP2132-Ab-1/ GM-Tg-rg-MP2132-Ab-2 | Anti-Rat FRS2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2132-Ab-1/ GM-Tg-mg-MP2132-Ab-2 | Anti-Mouse FRS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2132-Ab-1/ GM-Tg-cynog-MP2132-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FRS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2132-Ab-1/ GM-Tg-felg-MP2132-Ab-2 | Anti-Feline FRS2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2132-Ab-1/ GM-Tg-cang-MP2132-Ab-2 | Anti-Canine FRS2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2132-Ab-1/ GM-Tg-bovg-MP2132-Ab-2 | Anti-Bovine FRS2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2132-Ab-1/ GM-Tg-equg-MP2132-Ab-2 | Anti-Equine FRS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2132-Ab-1/ GM-Tg-hg-MP2132-Ab-2; GM-Tg-rg-MP2132-Ab-1/ GM-Tg-rg-MP2132-Ab-2; GM-Tg-mg-MP2132-Ab-1/ GM-Tg-mg-MP2132-Ab-2; GM-Tg-cynog-MP2132-Ab-1/ GM-Tg-cynog-MP2132-Ab-2; GM-Tg-felg-MP2132-Ab-1/ GM-Tg-felg-MP2132-Ab-2; GM-Tg-cang-MP2132-Ab-1/ GM-Tg-cang-MP2132-Ab-2; GM-Tg-bovg-MP2132-Ab-1/ GM-Tg-bovg-MP2132-Ab-2; GM-Tg-equg-MP2132-Ab-1/ GM-Tg-equg-MP2132-Ab-2 |
| Products Name | Anti-FRS2 monoclonal antibody |
| Format | mab |
| Target Name | FRS2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FRS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FRS2/ FRS1AA/ FRS2alpha VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP2132-Ag-1 | fibroblast growth factor receptor substrate 2 (FRS2) protein |
| ORF Viral Vector | vGMLP002758 | human FRS2 Lentivirus particle |
| ORF Viral Vector | pGMLP002758 | human FRS2 Lentivirus plasmid |
Target information
| Target ID | GM-MP2132 |
| Target Name | FRS2 |
| Gene ID | 10818,327826,314850,717117,474444,101099133,538624,100052205 |
| Gene Symbol and Synonyms | C330018A15Rik,FRS1A,FRS2,FRS2-alpha,FRS2A,FRS2alpha,SNT,SNT-1,SNT1 |
| Uniprot Accession | Q8WU20 |
| Uniprot Entry Name | FRS2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000166225 |
| Target Classification | N/A |
The target: FRS2, gene name: FRS2, also named as FRS1AA, FRS2alpha, SNT, SNT-1, SNT1, FRS2. Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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