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Anti-FLNB/ ABP-278/ ABP-280 monoclonal antibody
Anti-FLNB/ ABP-278/ ABP-280 antibody for FACS & in-vivo assay
Go to FLNB/FLNB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2126-Ab-1/ GM-Tg-hg-MP2126-Ab-2 | Anti-Human FLNB monoclonal antibody | Human |
| GM-Tg-rg-MP2126-Ab-1/ GM-Tg-rg-MP2126-Ab-2 | Anti-Rat FLNB monoclonal antibody | Rat |
| GM-Tg-mg-MP2126-Ab-1/ GM-Tg-mg-MP2126-Ab-2 | Anti-Mouse FLNB monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2126-Ab-1/ GM-Tg-cynog-MP2126-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FLNB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2126-Ab-1/ GM-Tg-felg-MP2126-Ab-2 | Anti-Feline FLNB monoclonal antibody | Feline |
| GM-Tg-cang-MP2126-Ab-1/ GM-Tg-cang-MP2126-Ab-2 | Anti-Canine FLNB monoclonal antibody | Canine |
| GM-Tg-bovg-MP2126-Ab-1/ GM-Tg-bovg-MP2126-Ab-2 | Anti-Bovine FLNB monoclonal antibody | Bovine |
| GM-Tg-equg-MP2126-Ab-1/ GM-Tg-equg-MP2126-Ab-2 | Anti-Equine FLNB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2126-Ab-1/ GM-Tg-hg-MP2126-Ab-2; GM-Tg-rg-MP2126-Ab-1/ GM-Tg-rg-MP2126-Ab-2; GM-Tg-mg-MP2126-Ab-1/ GM-Tg-mg-MP2126-Ab-2; GM-Tg-cynog-MP2126-Ab-1/ GM-Tg-cynog-MP2126-Ab-2; GM-Tg-felg-MP2126-Ab-1/ GM-Tg-felg-MP2126-Ab-2; GM-Tg-cang-MP2126-Ab-1/ GM-Tg-cang-MP2126-Ab-2; GM-Tg-bovg-MP2126-Ab-1/ GM-Tg-bovg-MP2126-Ab-2; GM-Tg-equg-MP2126-Ab-1/ GM-Tg-equg-MP2126-Ab-2 |
| Products Name | Anti-FLNB monoclonal antibody |
| Format | mab |
| Target Name | FLNB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FLNB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FLNB/ ABP-278/ ABP-280 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2126 |
| Target Name | FLNB |
| Gene ID | 2317,286940,306204,702732,484713,101098612,613533,100057963 |
| Gene Symbol and Synonyms | ABP-278,ABP-280,AOI,FH1,FLN-B,FLN1L,FLNB,LRS1,SCT,TABP,TAP |
| Uniprot Accession | O75369 |
| Uniprot Entry Name | FLNB_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Mucocutaneous lymph node syndrome [Kawasaki] |
| Gene Ensembl | ENSG00000136068 |
| Target Classification | N/A |
The target: FLNB, gene name: FLNB, also named as ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP. This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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