Anti-CTNA1/ CTNNA1/ CAP102 monoclonal antibody

Anti-CTNA1/ CTNNA1/ CAP102 antibody for FACS & in-vivo assay

Target products collectionGo to CTNNA1/CTNNA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2069-Ab-1/ GM-Tg-hg-MP2069-Ab-2Anti-Human CTNNA1 monoclonal antibodyHuman
GM-Tg-rg-MP2069-Ab-1/ GM-Tg-rg-MP2069-Ab-2Anti-Rat CTNNA1 monoclonal antibodyRat
GM-Tg-mg-MP2069-Ab-1/ GM-Tg-mg-MP2069-Ab-2Anti-Mouse CTNNA1 monoclonal antibodyMouse
GM-Tg-cynog-MP2069-Ab-1/ GM-Tg-cynog-MP2069-Ab-2Anti-Cynomolgus/ Rhesus macaque CTNNA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2069-Ab-1/ GM-Tg-felg-MP2069-Ab-2Anti-Feline CTNNA1 monoclonal antibodyFeline
GM-Tg-cang-MP2069-Ab-1/ GM-Tg-cang-MP2069-Ab-2Anti-Canine CTNNA1 monoclonal antibodyCanine
GM-Tg-bovg-MP2069-Ab-1/ GM-Tg-bovg-MP2069-Ab-2Anti-Bovine CTNNA1 monoclonal antibodyBovine
GM-Tg-equg-MP2069-Ab-1/ GM-Tg-equg-MP2069-Ab-2Anti-Equine CTNNA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2069-Ab-1/ GM-Tg-hg-MP2069-Ab-2; GM-Tg-rg-MP2069-Ab-1/ GM-Tg-rg-MP2069-Ab-2;
GM-Tg-mg-MP2069-Ab-1/ GM-Tg-mg-MP2069-Ab-2; GM-Tg-cynog-MP2069-Ab-1/ GM-Tg-cynog-MP2069-Ab-2;
GM-Tg-felg-MP2069-Ab-1/ GM-Tg-felg-MP2069-Ab-2; GM-Tg-cang-MP2069-Ab-1/ GM-Tg-cang-MP2069-Ab-2;
GM-Tg-bovg-MP2069-Ab-1/ GM-Tg-bovg-MP2069-Ab-2; GM-Tg-equg-MP2069-Ab-1/ GM-Tg-equg-MP2069-Ab-2
Products NameAnti-CTNNA1 monoclonal antibody
Formatmab
Target NameCTNNA1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CTNNA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CTNA1/ CTNNA1/ CAP102 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAD000493human CTNNA1 Adenovirus plasmid
    ORF Viral VectorvGMAD000500human CTNNA1 Adenovirus particle
    ORF Viral VectorpGMAD000130human CTNNA1 Adenovirus plasmid
    ORF Viral VectorpGMAD000500human CTNNA1 Adenovirus plasmid
    ORF Viral VectorvGMAD000130human CTNNA1 Adenovirus particle
    ORF Viral VectorvGMAD000493human CTNNA1 Adenovirus particle
    ORF Viral VectorpGMLPm004028mouse Ctnna1 Lentivirus plasmid
    ORF Viral VectorvGMLPm004028mouse Ctnna1 Lentivirus particle


    Target information

    Target IDGM-MP2069
    Target NameCTNNA1
    Gene ID1495,12385,307505,574385,474698,101089324,526848,100072548
    Gene Symbol and Synonyms2010010M04Rik,CAP102,Catna1,CTNNA1,MDBS2,MDPT2
    Uniprot AccessionP35221,Q3MHM6
    Uniprot Entry NameCTNA1_HUMAN,CTNA1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000044115
    Target ClassificationTumor-associated antigen (TAA)

    The target: CTNNA1, gene name: CTNNA1, also named as CAP102, MDPT2. This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.