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Anti-CKAP5/ CHTOG/ MSPS monoclonal antibody
Anti-CKAP5/ CHTOG/ MSPS antibody for FACS & in-vivo assay
Go to CKAP5/CKAP5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2056-Ab-1/ GM-Tg-hg-MP2056-Ab-2 | Anti-Human CKAP5 monoclonal antibody | Human |
| GM-Tg-rg-MP2056-Ab-1/ GM-Tg-rg-MP2056-Ab-2 | Anti-Rat CKAP5 monoclonal antibody | Rat |
| GM-Tg-mg-MP2056-Ab-1/ GM-Tg-mg-MP2056-Ab-2 | Anti-Mouse CKAP5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2056-Ab-1/ GM-Tg-cynog-MP2056-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CKAP5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2056-Ab-1/ GM-Tg-felg-MP2056-Ab-2 | Anti-Feline CKAP5 monoclonal antibody | Feline |
| GM-Tg-cang-MP2056-Ab-1/ GM-Tg-cang-MP2056-Ab-2 | Anti-Canine CKAP5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2056-Ab-1/ GM-Tg-bovg-MP2056-Ab-2 | Anti-Bovine CKAP5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2056-Ab-1/ GM-Tg-equg-MP2056-Ab-2 | Anti-Equine CKAP5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2056-Ab-1/ GM-Tg-hg-MP2056-Ab-2; GM-Tg-rg-MP2056-Ab-1/ GM-Tg-rg-MP2056-Ab-2; GM-Tg-mg-MP2056-Ab-1/ GM-Tg-mg-MP2056-Ab-2; GM-Tg-cynog-MP2056-Ab-1/ GM-Tg-cynog-MP2056-Ab-2; GM-Tg-felg-MP2056-Ab-1/ GM-Tg-felg-MP2056-Ab-2; GM-Tg-cang-MP2056-Ab-1/ GM-Tg-cang-MP2056-Ab-2; GM-Tg-bovg-MP2056-Ab-1/ GM-Tg-bovg-MP2056-Ab-2; GM-Tg-equg-MP2056-Ab-1/ GM-Tg-equg-MP2056-Ab-2 |
| Products Name | Anti-CKAP5 monoclonal antibody |
| Format | mab |
| Target Name | CKAP5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CKAP5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CKAP5/ CHTOG/ MSPS VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2056 |
| Target Name | CKAP5 |
| Gene ID | 9793,75786,311191,714095,475986,101090894,533980,100050886 |
| Gene Symbol and Synonyms | 3110043H24Rik,4930432B04Rik,ch-TOG,CHTOG,CKAP5,D730027C18Rik,mKIAA0097,MSPS,TOG,TOGp |
| Uniprot Accession | Q14008 |
| Uniprot Entry Name | CKAP5_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000175216 |
| Target Classification | N/A |
The target: CKAP5, gene name: CKAP5, also named as CHTOG, MSPS, TOG, TOGp, ch-TOG. This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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