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Anti-AMPH/ AMPH1 monoclonal antibody
Anti-AMPH/ AMPH1 antibody for FACS & in-vivo assay
Go to AMPH/AMPH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1987-Ab-1/ GM-Tg-hg-MP1987-Ab-2 | Anti-Human AMPH monoclonal antibody | Human |
| GM-Tg-rg-MP1987-Ab-1/ GM-Tg-rg-MP1987-Ab-2 | Anti-Rat AMPH monoclonal antibody | Rat |
| GM-Tg-mg-MP1987-Ab-1/ GM-Tg-mg-MP1987-Ab-2 | Anti-Mouse AMPH monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1987-Ab-1/ GM-Tg-cynog-MP1987-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AMPH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1987-Ab-1/ GM-Tg-felg-MP1987-Ab-2 | Anti-Feline AMPH monoclonal antibody | Feline |
| GM-Tg-cang-MP1987-Ab-1/ GM-Tg-cang-MP1987-Ab-2 | Anti-Canine AMPH monoclonal antibody | Canine |
| GM-Tg-bovg-MP1987-Ab-1/ GM-Tg-bovg-MP1987-Ab-2 | Anti-Bovine AMPH monoclonal antibody | Bovine |
| GM-Tg-equg-MP1987-Ab-1/ GM-Tg-equg-MP1987-Ab-2 | Anti-Equine AMPH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1987-Ab-1/ GM-Tg-hg-MP1987-Ab-2; GM-Tg-rg-MP1987-Ab-1/ GM-Tg-rg-MP1987-Ab-2; GM-Tg-mg-MP1987-Ab-1/ GM-Tg-mg-MP1987-Ab-2; GM-Tg-cynog-MP1987-Ab-1/ GM-Tg-cynog-MP1987-Ab-2; GM-Tg-felg-MP1987-Ab-1/ GM-Tg-felg-MP1987-Ab-2; GM-Tg-cang-MP1987-Ab-1/ GM-Tg-cang-MP1987-Ab-2; GM-Tg-bovg-MP1987-Ab-1/ GM-Tg-bovg-MP1987-Ab-2; GM-Tg-equg-MP1987-Ab-1/ GM-Tg-equg-MP1987-Ab-2 |
| Products Name | Anti-AMPH monoclonal antibody |
| Format | mab |
| Target Name | AMPH |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AMPH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AMPH/ AMPH1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003593 | mouse Amph Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003593 | mouse Amph Lentivirus particle |
Target information
| Target ID | GM-MP1987 |
| Target Name | AMPH |
| Gene ID | 273,218038,60668,704559,475877,101100039,614722,100062724 |
| Gene Symbol and Synonyms | AMPH,AMPH1 |
| Uniprot Accession | P49418,O08838 |
| Uniprot Entry Name | AMPH_HUMAN,AMPH_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000078053 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: AMPH, gene name: AMPH, also named as AMPH1. This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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