Anti-YBOX1/ YBX1/ BP-8 monoclonal antibody

Anti-YBOX1/ YBX1/ BP-8 antibody for FACS & in-vivo assay

Target products collectionGo to YBX1/YBX1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1951-Ab-1/ GM-Tg-hg-MP1951-Ab-2Anti-Human YBX1 monoclonal antibodyHuman
GM-Tg-rg-MP1951-Ab-1/ GM-Tg-rg-MP1951-Ab-2Anti-Rat YBX1 monoclonal antibodyRat
GM-Tg-mg-MP1951-Ab-1/ GM-Tg-mg-MP1951-Ab-2Anti-Mouse YBX1 monoclonal antibodyMouse
GM-Tg-cynog-MP1951-Ab-1/ GM-Tg-cynog-MP1951-Ab-2Anti-Cynomolgus/ Rhesus macaque YBX1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1951-Ab-1/ GM-Tg-felg-MP1951-Ab-2Anti-Feline YBX1 monoclonal antibodyFeline
GM-Tg-cang-MP1951-Ab-1/ GM-Tg-cang-MP1951-Ab-2Anti-Canine YBX1 monoclonal antibodyCanine
GM-Tg-bovg-MP1951-Ab-1/ GM-Tg-bovg-MP1951-Ab-2Anti-Bovine YBX1 monoclonal antibodyBovine
GM-Tg-equg-MP1951-Ab-1/ GM-Tg-equg-MP1951-Ab-2Anti-Equine YBX1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1951-Ab-1/ GM-Tg-hg-MP1951-Ab-2; GM-Tg-rg-MP1951-Ab-1/ GM-Tg-rg-MP1951-Ab-2;
GM-Tg-mg-MP1951-Ab-1/ GM-Tg-mg-MP1951-Ab-2; GM-Tg-cynog-MP1951-Ab-1/ GM-Tg-cynog-MP1951-Ab-2;
GM-Tg-felg-MP1951-Ab-1/ GM-Tg-felg-MP1951-Ab-2; GM-Tg-cang-MP1951-Ab-1/ GM-Tg-cang-MP1951-Ab-2;
GM-Tg-bovg-MP1951-Ab-1/ GM-Tg-bovg-MP1951-Ab-2; GM-Tg-equg-MP1951-Ab-1/ GM-Tg-equg-MP1951-Ab-2
Products NameAnti-YBX1 monoclonal antibody
Formatmab
Target NameYBX1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-YBX1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species YBOX1/ YBX1/ BP-8 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000237human YBX1 Lentivirus particle
    ORF Viral VectorpGMLV000237human YBX1 Lentivirus plasmid
    ORF Viral VectorpGMLV000809house mouse Ybx1 Lentivirus plasmid
    ORF Viral VectorvGMLV000809house mouse Ybx1 Lentivirus particle


    Target information

    Target IDGM-MP1951
    Target NameYBX1
    Gene ID4904,22608,500538,700140,607025,102900263,287023,100067336
    Gene Symbol and Synonyms1700102N10Rik,BP-8,Byb1,CBF-A,Cbfa,CSDA2,CSDB,DBPB,EF1A,EFI-A,MDR-NF1,MSY1,mYB-1a,NSEP-1,NSEP1,YB-1,YB1,YBX1
    Uniprot AccessionP67809,P62961,P67808
    Uniprot Entry NameYBOX1_HUMAN,YBOX1_RAT,YBOX1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000065978
    Target ClassificationTumor-associated antigen (TAA)

    The target: YBX1, gene name: YBX1, also named as BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1. This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.