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Anti-XCR1/ CCXCR1/ GPR5 monoclonal antibody
Anti-XCR1/ CCXCR1/ GPR5 antibody for FACS & in-vivo assay
Go to XCR1/XCR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1940-Ab-1/ GM-Tg-hg-MP1940-Ab-2 | Anti-Human XCR1 monoclonal antibody | Human |
| GM-Tg-rg-MP1940-Ab-1/ GM-Tg-rg-MP1940-Ab-2 | Anti-Rat XCR1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1940-Ab-1/ GM-Tg-mg-MP1940-Ab-2 | Anti-Mouse XCR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1940-Ab-1/ GM-Tg-cynog-MP1940-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XCR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1940-Ab-1/ GM-Tg-felg-MP1940-Ab-2 | Anti-Feline XCR1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1940-Ab-1/ GM-Tg-cang-MP1940-Ab-2 | Anti-Canine XCR1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1940-Ab-1/ GM-Tg-bovg-MP1940-Ab-2 | Anti-Bovine XCR1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1940-Ab-1/ GM-Tg-equg-MP1940-Ab-2 | Anti-Equine XCR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1940-Ab-1/ GM-Tg-hg-MP1940-Ab-2; GM-Tg-rg-MP1940-Ab-1/ GM-Tg-rg-MP1940-Ab-2; GM-Tg-mg-MP1940-Ab-1/ GM-Tg-mg-MP1940-Ab-2; GM-Tg-cynog-MP1940-Ab-1/ GM-Tg-cynog-MP1940-Ab-2; GM-Tg-felg-MP1940-Ab-1/ GM-Tg-felg-MP1940-Ab-2; GM-Tg-cang-MP1940-Ab-1/ GM-Tg-cang-MP1940-Ab-2; GM-Tg-bovg-MP1940-Ab-1/ GM-Tg-bovg-MP1940-Ab-2; GM-Tg-equg-MP1940-Ab-1/ GM-Tg-equg-MP1940-Ab-2 |
| Products Name | Anti-XCR1 monoclonal antibody |
| Format | mab |
| Target Name | XCR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-XCR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species XCR1/ CCXCR1/ GPR5 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1940-Ag-1 | X-C motif chemokine receptor 1 (XCR1) protein |
Target information
| Target ID | GM-MP1940 |
| Target Name | XCR1 |
| Gene ID | 2829,23832,301086,713622,484792,111558429,617880,100065485 |
| Gene Symbol and Synonyms | CCXCR1,GPR5,mXcr1,XCR1 |
| Uniprot Accession | P46094 |
| Uniprot Entry Name | XCR1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000173578 |
| Target Classification | GPCR |
The target: XCR1, gene name: XCR1, also named as CCXCR1, GPR5. The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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