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Anti-WNT4/ SERKAL/ WNT-4 monoclonal antibody
Anti-WNT4/ SERKAL/ WNT-4 antibody for FACS & in-vivo assay
Go to WNT4/WNT4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1936-Ab-1/ GM-Tg-hg-MP1936-Ab-2 | Anti-Human WNT4 monoclonal antibody | Human |
| GM-Tg-rg-MP1936-Ab-1/ GM-Tg-rg-MP1936-Ab-2 | Anti-Rat WNT4 monoclonal antibody | Rat |
| GM-Tg-mg-MP1936-Ab-1/ GM-Tg-mg-MP1936-Ab-2 | Anti-Mouse WNT4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1936-Ab-1/ GM-Tg-cynog-MP1936-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WNT4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1936-Ab-1/ GM-Tg-felg-MP1936-Ab-2 | Anti-Feline WNT4 monoclonal antibody | Feline |
| GM-Tg-cang-MP1936-Ab-1/ GM-Tg-cang-MP1936-Ab-2 | Anti-Canine WNT4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1936-Ab-1/ GM-Tg-bovg-MP1936-Ab-2 | Anti-Bovine WNT4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1936-Ab-1/ GM-Tg-equg-MP1936-Ab-2 | Anti-Equine WNT4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1936-Ab-1/ GM-Tg-hg-MP1936-Ab-2; GM-Tg-rg-MP1936-Ab-1/ GM-Tg-rg-MP1936-Ab-2; GM-Tg-mg-MP1936-Ab-1/ GM-Tg-mg-MP1936-Ab-2; GM-Tg-cynog-MP1936-Ab-1/ GM-Tg-cynog-MP1936-Ab-2; GM-Tg-felg-MP1936-Ab-1/ GM-Tg-felg-MP1936-Ab-2; GM-Tg-cang-MP1936-Ab-1/ GM-Tg-cang-MP1936-Ab-2; GM-Tg-bovg-MP1936-Ab-1/ GM-Tg-bovg-MP1936-Ab-2; GM-Tg-equg-MP1936-Ab-1/ GM-Tg-equg-MP1936-Ab-2 |
| Products Name | Anti-WNT4 monoclonal antibody |
| Format | mab |
| Target Name | WNT4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-WNT4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species WNT4/ SERKAL/ WNT-4 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1936-Ag-1 | wingless-type MMTV integration site family, member 4 (WNT4) protein |
| ORF Viral Vector | pGMLPm001098 | mouse Wnt4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001098 | mouse Wnt4 Lentivirus particle |
Target information
| Target ID | GM-MP1936 |
| Target Name | WNT4 |
| Gene ID | 54361,22417,84426,707864,612367,101095185,789600,100071678 |
| Gene Symbol and Synonyms | SERKAL,WNT-4,WNT4 |
| Uniprot Accession | P56705,Q9QXQ5 |
| Uniprot Entry Name | WNT4_HUMAN,WNT4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Injury to Kidney |
| Gene Ensembl | ENSG00000162552 |
| Target Classification | N/A |
The target: WNT4, gene name: WNT4, also named as SERKAL, WNT-4. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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