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Anti-WNT3/ INT4/ TETAMS monoclonal antibody
Anti-WNT3/ INT4/ TETAMS antibody for FACS & in-vivo assay
Go to WNT3/WNT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1935-Ab-1/ GM-Tg-hg-MP1935-Ab-2 | Anti-Human WNT3 monoclonal antibody | Human |
| GM-Tg-rg-MP1935-Ab-1/ GM-Tg-rg-MP1935-Ab-2 | Anti-Rat WNT3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1935-Ab-1/ GM-Tg-mg-MP1935-Ab-2 | Anti-Mouse WNT3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1935-Ab-1/ GM-Tg-cynog-MP1935-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WNT3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1935-Ab-1/ GM-Tg-felg-MP1935-Ab-2 | Anti-Feline WNT3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1935-Ab-1/ GM-Tg-cang-MP1935-Ab-2 | Anti-Canine WNT3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1935-Ab-1/ GM-Tg-bovg-MP1935-Ab-2 | Anti-Bovine WNT3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1935-Ab-1/ GM-Tg-equg-MP1935-Ab-2 | Anti-Equine WNT3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1935-Ab-1/ GM-Tg-hg-MP1935-Ab-2; GM-Tg-rg-MP1935-Ab-1/ GM-Tg-rg-MP1935-Ab-2; GM-Tg-mg-MP1935-Ab-1/ GM-Tg-mg-MP1935-Ab-2; GM-Tg-cynog-MP1935-Ab-1/ GM-Tg-cynog-MP1935-Ab-2; GM-Tg-felg-MP1935-Ab-1/ GM-Tg-felg-MP1935-Ab-2; GM-Tg-cang-MP1935-Ab-1/ GM-Tg-cang-MP1935-Ab-2; GM-Tg-bovg-MP1935-Ab-1/ GM-Tg-bovg-MP1935-Ab-2; GM-Tg-equg-MP1935-Ab-1/ GM-Tg-equg-MP1935-Ab-2 |
| Products Name | Anti-WNT3 monoclonal antibody |
| Format | mab |
| Target Name | WNT3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-WNT3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species WNT3/ INT4/ TETAMS VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1935-Ag-1 | wingless-related MMTV integration site 3 (WNT3) protein |
| ORF Viral Vector | vGMLP002254 | human WNT3 Lentivirus particle |
| ORF Viral Vector | pGMLP002254 | human WNT3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002905 | mouse Wnt3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002905 | mouse Wnt3 Lentivirus particle |
Target information
| Target ID | GM-MP1935 |
| Target Name | WNT3 |
| Gene ID | 7473,22415,24882,716909,609107,101088533,540753,100049880 |
| Gene Symbol and Synonyms | Int-4,INT4,TETAMS,Wnt-3,WNT3 |
| Uniprot Accession | P56703 |
| Uniprot Entry Name | WNT3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000108379 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: WNT3, gene name: WNT3, also named as INT4, TETAMS. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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