Anti-WNT1/ BMND16/ INT1 monoclonal antibody

Anti-WNT1/ BMND16/ INT1 antibody for FACS & in-vivo assay

Target products collectionGo to WNT1/WNT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1934-Ab-1/ GM-Tg-hg-MP1934-Ab-2Anti-Human WNT1 monoclonal antibodyHuman
GM-Tg-rg-MP1934-Ab-1/ GM-Tg-rg-MP1934-Ab-2Anti-Rat WNT1 monoclonal antibodyRat
GM-Tg-mg-MP1934-Ab-1/ GM-Tg-mg-MP1934-Ab-2Anti-Mouse WNT1 monoclonal antibodyMouse
GM-Tg-cynog-MP1934-Ab-1/ GM-Tg-cynog-MP1934-Ab-2Anti-Cynomolgus/ Rhesus macaque WNT1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1934-Ab-1/ GM-Tg-felg-MP1934-Ab-2Anti-Feline WNT1 monoclonal antibodyFeline
GM-Tg-cang-MP1934-Ab-1/ GM-Tg-cang-MP1934-Ab-2Anti-Canine WNT1 monoclonal antibodyCanine
GM-Tg-bovg-MP1934-Ab-1/ GM-Tg-bovg-MP1934-Ab-2Anti-Bovine WNT1 monoclonal antibodyBovine
GM-Tg-equg-MP1934-Ab-1/ GM-Tg-equg-MP1934-Ab-2Anti-Equine WNT1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1934-Ab-1/ GM-Tg-hg-MP1934-Ab-2; GM-Tg-rg-MP1934-Ab-1/ GM-Tg-rg-MP1934-Ab-2;
GM-Tg-mg-MP1934-Ab-1/ GM-Tg-mg-MP1934-Ab-2; GM-Tg-cynog-MP1934-Ab-1/ GM-Tg-cynog-MP1934-Ab-2;
GM-Tg-felg-MP1934-Ab-1/ GM-Tg-felg-MP1934-Ab-2; GM-Tg-cang-MP1934-Ab-1/ GM-Tg-cang-MP1934-Ab-2;
GM-Tg-bovg-MP1934-Ab-1/ GM-Tg-bovg-MP1934-Ab-2; GM-Tg-equg-MP1934-Ab-1/ GM-Tg-equg-MP1934-Ab-2
Products NameAnti-WNT1 monoclonal antibody
Formatmab
Target NameWNT1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-WNT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species WNT1/ BMND16/ INT1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP1934-Ag-1wingless-type MMTV integration site family, member 1 (WNT1) protein
    ORF Viral VectorpGMAD000604human WNT1 Adenovirus plasmid
    ORF Viral VectorpGMLP002016human WNT1 Lentivirus plasmid
    ORF Viral VectorvGMAD000604human WNT1 Adenovirus particle
    ORF Viral VectorvGMLP002016human WNT1 Lentivirus particle
    ORF Viral VectorpGMAAV000077mouse Wnt1 AAV plasmid
    ORF Viral VectorvGMAAV000077mouse Wnt1 AAV particle


    Target information

    Target IDGM-MP1934
    Target NameWNT1
    Gene ID7471,22408,24881,709009,486560,101094190,540662,100058859
    Gene Symbol and SynonymsBMND16,Int-1,INT1,OI15,sw,swaying,Wnt-1,WNT1
    Uniprot AccessionP04628
    Uniprot Entry NameWNT1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000125084
    Target ClassificationTumor-associated antigen (TAA)

    The target: WNT1, gene name: WNT1, also named as BMND16, INT1, OI15. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However,  further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.