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Anti-VNN1/ HDLCQ8/ Tiff66 monoclonal antibody
Anti-VNN1/ HDLCQ8/ Tiff66 antibody for FACS & in-vivo assay
Go to VNN1/VNN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1927-Ab-1/ GM-Tg-hg-MP1927-Ab-2 | Anti-Human VNN1 monoclonal antibody | Human |
| GM-Tg-rg-MP1927-Ab-1/ GM-Tg-rg-MP1927-Ab-2 | Anti-Rat VNN1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1927-Ab-1/ GM-Tg-mg-MP1927-Ab-2 | Anti-Mouse VNN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1927-Ab-1/ GM-Tg-cynog-MP1927-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VNN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1927-Ab-1/ GM-Tg-felg-MP1927-Ab-2 | Anti-Feline VNN1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1927-Ab-1/ GM-Tg-cang-MP1927-Ab-2 | Anti-Canine VNN1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1927-Ab-1/ GM-Tg-bovg-MP1927-Ab-2 | Anti-Bovine VNN1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1927-Ab-1/ GM-Tg-equg-MP1927-Ab-2 | Anti-Equine VNN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1927-Ab-1/ GM-Tg-hg-MP1927-Ab-2; GM-Tg-rg-MP1927-Ab-1/ GM-Tg-rg-MP1927-Ab-2; GM-Tg-mg-MP1927-Ab-1/ GM-Tg-mg-MP1927-Ab-2; GM-Tg-cynog-MP1927-Ab-1/ GM-Tg-cynog-MP1927-Ab-2; GM-Tg-felg-MP1927-Ab-1/ GM-Tg-felg-MP1927-Ab-2; GM-Tg-cang-MP1927-Ab-1/ GM-Tg-cang-MP1927-Ab-2; GM-Tg-bovg-MP1927-Ab-1/ GM-Tg-bovg-MP1927-Ab-2; GM-Tg-equg-MP1927-Ab-1/ GM-Tg-equg-MP1927-Ab-2 |
| Products Name | Anti-VNN1 monoclonal antibody |
| Format | mab |
| Target Name | VNN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-VNN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species VNN1/ HDLCQ8/ Tiff66 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1927 |
| Target Name | VNN1 |
| Gene ID | 8876,22361,29142,526704 |
| Gene Symbol and Synonyms | HDLCQ8,Tiff66,V-1,VNN1 |
| Uniprot Accession | O95497,Q58CQ9 |
| Uniprot Entry Name | VNN1_HUMAN,VNN1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112299 |
| Target Classification | N/A |
The target: VNN1, gene name: VNN1, also named as HDLCQ8, Tiff66. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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