Anti-USE1/ D12/ MDS032 monoclonal antibody

Anti-USE1/ D12/ MDS032 antibody for FACS & in-vivo assay

Target products collectionGo to USE1/USE1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1910-Ab-1/ GM-Tg-hg-MP1910-Ab-2Anti-Human USE1 monoclonal antibodyHuman
GM-Tg-rg-MP1910-Ab-1/ GM-Tg-rg-MP1910-Ab-2Anti-Rat USE1 monoclonal antibodyRat
GM-Tg-mg-MP1910-Ab-1/ GM-Tg-mg-MP1910-Ab-2Anti-Mouse USE1 monoclonal antibodyMouse
GM-Tg-cynog-MP1910-Ab-1/ GM-Tg-cynog-MP1910-Ab-2Anti-Cynomolgus/ Rhesus macaque USE1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1910-Ab-1/ GM-Tg-felg-MP1910-Ab-2Anti-Feline USE1 monoclonal antibodyFeline
GM-Tg-cang-MP1910-Ab-1/ GM-Tg-cang-MP1910-Ab-2Anti-Canine USE1 monoclonal antibodyCanine
GM-Tg-bovg-MP1910-Ab-1/ GM-Tg-bovg-MP1910-Ab-2Anti-Bovine USE1 monoclonal antibodyBovine
GM-Tg-equg-MP1910-Ab-1/ GM-Tg-equg-MP1910-Ab-2Anti-Equine USE1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1910-Ab-1/ GM-Tg-hg-MP1910-Ab-2; GM-Tg-rg-MP1910-Ab-1/ GM-Tg-rg-MP1910-Ab-2;
GM-Tg-mg-MP1910-Ab-1/ GM-Tg-mg-MP1910-Ab-2; GM-Tg-cynog-MP1910-Ab-1/ GM-Tg-cynog-MP1910-Ab-2;
GM-Tg-felg-MP1910-Ab-1/ GM-Tg-felg-MP1910-Ab-2; GM-Tg-cang-MP1910-Ab-1/ GM-Tg-cang-MP1910-Ab-2;
GM-Tg-bovg-MP1910-Ab-1/ GM-Tg-bovg-MP1910-Ab-2; GM-Tg-equg-MP1910-Ab-1/ GM-Tg-equg-MP1910-Ab-2
Products NameAnti-USE1 monoclonal antibody
Formatmab
Target NameUSE1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-USE1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species USE1/ D12/ MDS032 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1910
    Target NameUSE1
    Gene ID55850,67023,290627,718905,609734,101095556,512890,100070008
    Gene Symbol and Synonyms2010315L10Rik,5730403H22Rik,D12,Ed2,MDS032,P31,Q-snare,RGD1306660,SLT1,USE1
    Uniprot AccessionQ9NZ43
    Uniprot Entry NameUSE1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000053501
    Target ClassificationN/A

    The target: USE1, gene name: USE1, also named as D12, MDS032, P31, SLT1. Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.