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Anti-ULBP2/ ALCAN-alpha/ N2DL2 monoclonal antibody
Anti-ULBP2/ ALCAN-alpha/ N2DL2 antibody for FACS & in-vivo assay
Go to ULBP2/ULBP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1899-Ab-1/ GM-Tg-hg-MP1899-Ab-2 | Anti-Human ULBP2 monoclonal antibody | Human |
| GM-Tg-rg-MP1899-Ab-1/ GM-Tg-rg-MP1899-Ab-2 | Anti-Rat ULBP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1899-Ab-1/ GM-Tg-mg-MP1899-Ab-2 | Anti-Mouse ULBP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1899-Ab-1/ GM-Tg-cynog-MP1899-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ULBP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1899-Ab-1/ GM-Tg-felg-MP1899-Ab-2 | Anti-Feline ULBP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1899-Ab-1/ GM-Tg-cang-MP1899-Ab-2 | Anti-Canine ULBP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1899-Ab-1/ GM-Tg-bovg-MP1899-Ab-2 | Anti-Bovine ULBP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1899-Ab-1/ GM-Tg-equg-MP1899-Ab-2 | Anti-Equine ULBP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1899-Ab-1/ GM-Tg-hg-MP1899-Ab-2; GM-Tg-rg-MP1899-Ab-1/ GM-Tg-rg-MP1899-Ab-2; GM-Tg-mg-MP1899-Ab-1/ GM-Tg-mg-MP1899-Ab-2; GM-Tg-cynog-MP1899-Ab-1/ GM-Tg-cynog-MP1899-Ab-2; GM-Tg-felg-MP1899-Ab-1/ GM-Tg-felg-MP1899-Ab-2; GM-Tg-cang-MP1899-Ab-1/ GM-Tg-cang-MP1899-Ab-2; GM-Tg-bovg-MP1899-Ab-1/ GM-Tg-bovg-MP1899-Ab-2; GM-Tg-equg-MP1899-Ab-1/ GM-Tg-equg-MP1899-Ab-2 |
| Products Name | Anti-ULBP2 monoclonal antibody |
| Format | mab |
| Target Name | ULBP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ULBP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ULBP2/ ALCAN-alpha/ N2DL2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004713 | human ULBP2 Lentivirus particle |
| ORF Viral Vector | pGMLP004713 | human ULBP2 Lentivirus plasmid |
Target information
| Target ID | GM-MP1899 |
| Target Name | ULBP2 |
| Gene ID | 80328 |
| Gene Symbol and Synonyms | ALCAN-alpha,N2DL2,NKG2DL2,RAET1H,RAET1L,ULBP2 |
| Uniprot Accession | Q9BZM5 |
| Uniprot Entry Name | ULBP2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000131015 |
| Target Classification | N/A |
The target: ULBP2, gene name: ULBP2, also named as ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, RAET1L. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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