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Anti-TNR19/ TNFRSF19/ TAJ monoclonal antibody
Anti-TNR19/ TNFRSF19/ TAJ antibody for FACS & in-vivo assay
Go to TNFRSF19/TNFRSF19 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1856-Ab-1/ GM-Tg-hg-MP1856-Ab-2 | Anti-Human TNFRSF19 monoclonal antibody | Human |
| GM-Tg-rg-MP1856-Ab-1/ GM-Tg-rg-MP1856-Ab-2 | Anti-Rat TNFRSF19 monoclonal antibody | Rat |
| GM-Tg-mg-MP1856-Ab-1/ GM-Tg-mg-MP1856-Ab-2 | Anti-Mouse TNFRSF19 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1856-Ab-1/ GM-Tg-cynog-MP1856-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFRSF19 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1856-Ab-1/ GM-Tg-felg-MP1856-Ab-2 | Anti-Feline TNFRSF19 monoclonal antibody | Feline |
| GM-Tg-cang-MP1856-Ab-1/ GM-Tg-cang-MP1856-Ab-2 | Anti-Canine TNFRSF19 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1856-Ab-1/ GM-Tg-bovg-MP1856-Ab-2 | Anti-Bovine TNFRSF19 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1856-Ab-1/ GM-Tg-equg-MP1856-Ab-2 | Anti-Equine TNFRSF19 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1856-Ab-1/ GM-Tg-hg-MP1856-Ab-2; GM-Tg-rg-MP1856-Ab-1/ GM-Tg-rg-MP1856-Ab-2; GM-Tg-mg-MP1856-Ab-1/ GM-Tg-mg-MP1856-Ab-2; GM-Tg-cynog-MP1856-Ab-1/ GM-Tg-cynog-MP1856-Ab-2; GM-Tg-felg-MP1856-Ab-1/ GM-Tg-felg-MP1856-Ab-2; GM-Tg-cang-MP1856-Ab-1/ GM-Tg-cang-MP1856-Ab-2; GM-Tg-bovg-MP1856-Ab-1/ GM-Tg-bovg-MP1856-Ab-2; GM-Tg-equg-MP1856-Ab-1/ GM-Tg-equg-MP1856-Ab-2 |
| Products Name | Anti-TNFRSF19 monoclonal antibody |
| Format | mab |
| Target Name | TNFRSF19 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFRSF19 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNR19/ TNFRSF19/ TAJ VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1856-Ag-1 | tumor necrosis factor receptor superfamily, member 19 (TNFRSF19) protein |
| ORF Viral Vector | pGMLPm001998 | mouse Tnfrsf19 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001998 | mouse Tnfrsf19 Lentivirus particle |
Target information
| Target ID | GM-MP1856 |
| Target Name | TNFRSF19 |
| Gene ID | 55504,29820,290300,707034,486042,101095303,768037,100057564 |
| Gene Symbol and Synonyms | RGD1564996,TAJ,TAJ-alpha,TNFRSF19,TRADE,TROY |
| Uniprot Accession | Q9NS68 |
| Uniprot Entry Name | TNR19_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000127863 |
| Target Classification | N/A |
The target: TNFRSF19, gene name: TNFRSF19, also named as TAJ, TAJ-alpha, TRADE, TROY. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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