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Anti-TR10C/ TNFRSF10C/ CD263 monoclonal antibody
Anti-TR10C/ TNFRSF10C/ CD263 antibody for FACS & in-vivo assay
Go to TNFRSF10C/TNFRSF10C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1854-Ab-1/ GM-Tg-hg-MP1854-Ab-2 | Anti-Human TNFRSF10C monoclonal antibody | Human |
| GM-Tg-rg-MP1854-Ab-1/ GM-Tg-rg-MP1854-Ab-2 | Anti-Rat TNFRSF10C monoclonal antibody | Rat |
| GM-Tg-mg-MP1854-Ab-1/ GM-Tg-mg-MP1854-Ab-2 | Anti-Mouse TNFRSF10C monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1854-Ab-1/ GM-Tg-cynog-MP1854-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFRSF10C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1854-Ab-1/ GM-Tg-felg-MP1854-Ab-2 | Anti-Feline TNFRSF10C monoclonal antibody | Feline |
| GM-Tg-cang-MP1854-Ab-1/ GM-Tg-cang-MP1854-Ab-2 | Anti-Canine TNFRSF10C monoclonal antibody | Canine |
| GM-Tg-bovg-MP1854-Ab-1/ GM-Tg-bovg-MP1854-Ab-2 | Anti-Bovine TNFRSF10C monoclonal antibody | Bovine |
| GM-Tg-equg-MP1854-Ab-1/ GM-Tg-equg-MP1854-Ab-2 | Anti-Equine TNFRSF10C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1854-Ab-1/ GM-Tg-hg-MP1854-Ab-2; GM-Tg-rg-MP1854-Ab-1/ GM-Tg-rg-MP1854-Ab-2; GM-Tg-mg-MP1854-Ab-1/ GM-Tg-mg-MP1854-Ab-2; GM-Tg-cynog-MP1854-Ab-1/ GM-Tg-cynog-MP1854-Ab-2; GM-Tg-felg-MP1854-Ab-1/ GM-Tg-felg-MP1854-Ab-2; GM-Tg-cang-MP1854-Ab-1/ GM-Tg-cang-MP1854-Ab-2; GM-Tg-bovg-MP1854-Ab-1/ GM-Tg-bovg-MP1854-Ab-2; GM-Tg-equg-MP1854-Ab-1/ GM-Tg-equg-MP1854-Ab-2 |
| Products Name | Anti-TNFRSF10C monoclonal antibody |
| Format | mab |
| Target Name | TNFRSF10C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFRSF10C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TR10C/ TNFRSF10C/ CD263 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1854-Ag-1 | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C) protein |
| ORF Viral Vector | pGMLP002252 | human TNFRSF10C Lentivirus plasmid |
| ORF Viral Vector | vGMLP002252 | human TNFRSF10C Lentivirus particle |
Target information
| Target ID | GM-MP1854 |
| Target Name | TNFRSF10C |
| Gene ID | 8794,100430035 |
| Gene Symbol and Synonyms | CD263,DCR1,DCR1-TNFR,LIT,TNFRSF10C,TRAIL-R3,TRAILR3,TRID |
| Uniprot Accession | O14798 |
| Uniprot Entry Name | TR10C_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000173535 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: TNFRSF10C, gene name: TNFRSF10C, also named as CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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