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Anti-TEFF2/ ™EFF2/ CT120.2 monoclonal antibody
Anti-TEFF2/ ™EFF2/ CT120.2 antibody for FACS & in-vivo assay
Go to ™EFF2/™EFF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1810-Ab-1/ GM-Tg-hg-MP1810-Ab-2 | Anti-Human ™EFF2 monoclonal antibody | Human |
| GM-Tg-rg-MP1810-Ab-1/ GM-Tg-rg-MP1810-Ab-2 | Anti-Rat ™EFF2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1810-Ab-1/ GM-Tg-mg-MP1810-Ab-2 | Anti-Mouse ™EFF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1810-Ab-1/ GM-Tg-cynog-MP1810-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™EFF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1810-Ab-1/ GM-Tg-felg-MP1810-Ab-2 | Anti-Feline ™EFF2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1810-Ab-1/ GM-Tg-cang-MP1810-Ab-2 | Anti-Canine ™EFF2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1810-Ab-1/ GM-Tg-bovg-MP1810-Ab-2 | Anti-Bovine ™EFF2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1810-Ab-1/ GM-Tg-equg-MP1810-Ab-2 | Anti-Equine ™EFF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1810-Ab-1/ GM-Tg-hg-MP1810-Ab-2; GM-Tg-rg-MP1810-Ab-1/ GM-Tg-rg-MP1810-Ab-2; GM-Tg-mg-MP1810-Ab-1/ GM-Tg-mg-MP1810-Ab-2; GM-Tg-cynog-MP1810-Ab-1/ GM-Tg-cynog-MP1810-Ab-2; GM-Tg-felg-MP1810-Ab-1/ GM-Tg-felg-MP1810-Ab-2; GM-Tg-cang-MP1810-Ab-1/ GM-Tg-cang-MP1810-Ab-2; GM-Tg-bovg-MP1810-Ab-1/ GM-Tg-bovg-MP1810-Ab-2; GM-Tg-equg-MP1810-Ab-1/ GM-Tg-equg-MP1810-Ab-2 |
| Products Name | Anti-™EFF2 monoclonal antibody |
| Format | mab |
| Target Name | ™EFF2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-™EFF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TEFF2/ ™EFF2/ CT120.2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1810-Ag-1 | Transmembrane protein with EGF-like and two follistatin-like domains 2 (™EFF2) protein |
| ORF Viral Vector | vGMLP001589 | human ™EFF2 Lentivirus particle |
| ORF Viral Vector | pGMLP001589 | human ™EFF2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002930 | mouse Tmeff2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002930 | mouse Tmeff2 Lentivirus particle |
Target information
| Target ID | GM-MP1810 |
| Target Name | ™EFF2 |
| Gene ID | 23671,56363,363228,694555,478848,101085308,538354,100054833 |
| Gene Symbol and Synonyms | 4832418D20Rik,7630402F16Rik,CT120.2,HPP1,TENB2,™EFF2,TPEF,TR,TR-2 |
| Uniprot Accession | Q9UIK5,Q17QD6 |
| Uniprot Entry Name | TEFF2_HUMAN,TEFF2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Esophagus Cancer |
| Gene Ensembl | ENSG00000144339 |
| Target Classification | N/A |
The target: ™EFF2, gene name: ™EFF2, also named as CT120.2, HPP1, TENB2, TPEF, TR, TR-2. This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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