Anti-SPRE3/ SPRED3/ Eve-3 monoclonal antibody

Anti-SPRE3/ SPRED3/ Eve-3 antibody for FACS & in-vivo assay

Target products collectionGo to SPRED3/SPRED3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1707-Ab-1/ GM-Tg-hg-MP1707-Ab-2Anti-Human SPRED3 monoclonal antibodyHuman
GM-Tg-rg-MP1707-Ab-1/ GM-Tg-rg-MP1707-Ab-2Anti-Rat SPRED3 monoclonal antibodyRat
GM-Tg-mg-MP1707-Ab-1/ GM-Tg-mg-MP1707-Ab-2Anti-Mouse SPRED3 monoclonal antibodyMouse
GM-Tg-cynog-MP1707-Ab-1/ GM-Tg-cynog-MP1707-Ab-2Anti-Cynomolgus/ Rhesus macaque SPRED3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1707-Ab-1/ GM-Tg-felg-MP1707-Ab-2Anti-Feline SPRED3 monoclonal antibodyFeline
GM-Tg-cang-MP1707-Ab-1/ GM-Tg-cang-MP1707-Ab-2Anti-Canine SPRED3 monoclonal antibodyCanine
GM-Tg-bovg-MP1707-Ab-1/ GM-Tg-bovg-MP1707-Ab-2Anti-Bovine SPRED3 monoclonal antibodyBovine
GM-Tg-equg-MP1707-Ab-1/ GM-Tg-equg-MP1707-Ab-2Anti-Equine SPRED3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1707-Ab-1/ GM-Tg-hg-MP1707-Ab-2; GM-Tg-rg-MP1707-Ab-1/ GM-Tg-rg-MP1707-Ab-2;
GM-Tg-mg-MP1707-Ab-1/ GM-Tg-mg-MP1707-Ab-2; GM-Tg-cynog-MP1707-Ab-1/ GM-Tg-cynog-MP1707-Ab-2;
GM-Tg-felg-MP1707-Ab-1/ GM-Tg-felg-MP1707-Ab-2; GM-Tg-cang-MP1707-Ab-1/ GM-Tg-cang-MP1707-Ab-2;
GM-Tg-bovg-MP1707-Ab-1/ GM-Tg-bovg-MP1707-Ab-2; GM-Tg-equg-MP1707-Ab-1/ GM-Tg-equg-MP1707-Ab-2
Products NameAnti-SPRED3 monoclonal antibody
Formatmab
Target NameSPRED3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPRED3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPRE3/ SPRED3/ Eve-3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1707
    Target NameSPRED3
    Gene ID399473,101809,308478,715133,612575,101094970,613633,111775189
    Gene Symbol and SynonymsD130060H24Rik,Eve-3,RGD1311713,spred-3,SPRED3
    Uniprot AccessionQ2MJR0
    Uniprot Entry NameSPRE3_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000188766
    Target ClassificationN/A

    The target: SPRED3, gene name: SPRED3, also named as Eve-3, spred-3. This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.