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Anti-S22A5/ SLC22A5/ CDSP monoclonal antibody
Anti-S22A5/ SLC22A5/ CDSP antibody for FACS & in-vivo assay
Go to SLC22A5/SLC22A5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1564-Ab-1/ GM-Tg-hg-MP1564-Ab-2 | Anti-Human SLC22A5 monoclonal antibody | Human |
| GM-Tg-rg-MP1564-Ab-1/ GM-Tg-rg-MP1564-Ab-2 | Anti-Rat SLC22A5 monoclonal antibody | Rat |
| GM-Tg-mg-MP1564-Ab-1/ GM-Tg-mg-MP1564-Ab-2 | Anti-Mouse SLC22A5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1564-Ab-1/ GM-Tg-cynog-MP1564-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC22A5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1564-Ab-1/ GM-Tg-felg-MP1564-Ab-2 | Anti-Feline SLC22A5 monoclonal antibody | Feline |
| GM-Tg-cang-MP1564-Ab-1/ GM-Tg-cang-MP1564-Ab-2 | Anti-Canine SLC22A5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1564-Ab-1/ GM-Tg-bovg-MP1564-Ab-2 | Anti-Bovine SLC22A5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1564-Ab-1/ GM-Tg-equg-MP1564-Ab-2 | Anti-Equine SLC22A5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1564-Ab-1/ GM-Tg-hg-MP1564-Ab-2; GM-Tg-rg-MP1564-Ab-1/ GM-Tg-rg-MP1564-Ab-2; GM-Tg-mg-MP1564-Ab-1/ GM-Tg-mg-MP1564-Ab-2; GM-Tg-cynog-MP1564-Ab-1/ GM-Tg-cynog-MP1564-Ab-2; GM-Tg-felg-MP1564-Ab-1/ GM-Tg-felg-MP1564-Ab-2; GM-Tg-cang-MP1564-Ab-1/ GM-Tg-cang-MP1564-Ab-2; GM-Tg-bovg-MP1564-Ab-1/ GM-Tg-bovg-MP1564-Ab-2; GM-Tg-equg-MP1564-Ab-1/ GM-Tg-equg-MP1564-Ab-2 |
| Products Name | Anti-SLC22A5 monoclonal antibody |
| Format | mab |
| Target Name | SLC22A5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC22A5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S22A5/ SLC22A5/ CDSP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002753 | mouse Slc22a5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002753 | mouse Slc22a5 Lentivirus particle |
Target information
| Target ID | GM-MP1564 |
| Target Name | SLC22A5 |
| Gene ID | 6584,20520,29726,707590,541266,100072871 |
| Gene Symbol and Synonyms | CDSP,CT1,jvs,Lstpl,OCTN2,SLC22A5,UST2r |
| Uniprot Accession | O76082,O70594 |
| Uniprot Entry Name | S22A5_HUMAN,S22A5_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000197375 |
| Target Classification | N/A |
The target: SLC22A5, gene name: SLC22A5, also named as CDSP, OCTN2. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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