Anti-SIGL6/ SIGLEC6/ CD327 monoclonal antibody

Anti-SIGL6/ SIGLEC6/ CD327 antibody for FACS & in-vivo assay

Target products collectionGo to SIGLEC6/SIGLEC6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1523-Ab-1/ GM-Tg-hg-MP1523-Ab-2Anti-Human SIGLEC6 monoclonal antibodyHuman
GM-Tg-rg-MP1523-Ab-1/ GM-Tg-rg-MP1523-Ab-2Anti-Rat SIGLEC6 monoclonal antibodyRat
GM-Tg-mg-MP1523-Ab-1/ GM-Tg-mg-MP1523-Ab-2Anti-Mouse SIGLEC6 monoclonal antibodyMouse
GM-Tg-cynog-MP1523-Ab-1/ GM-Tg-cynog-MP1523-Ab-2Anti-Cynomolgus/ Rhesus macaque SIGLEC6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1523-Ab-1/ GM-Tg-felg-MP1523-Ab-2Anti-Feline SIGLEC6 monoclonal antibodyFeline
GM-Tg-cang-MP1523-Ab-1/ GM-Tg-cang-MP1523-Ab-2Anti-Canine SIGLEC6 monoclonal antibodyCanine
GM-Tg-bovg-MP1523-Ab-1/ GM-Tg-bovg-MP1523-Ab-2Anti-Bovine SIGLEC6 monoclonal antibodyBovine
GM-Tg-equg-MP1523-Ab-1/ GM-Tg-equg-MP1523-Ab-2Anti-Equine SIGLEC6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1523-Ab-1/ GM-Tg-hg-MP1523-Ab-2; GM-Tg-rg-MP1523-Ab-1/ GM-Tg-rg-MP1523-Ab-2;
GM-Tg-mg-MP1523-Ab-1/ GM-Tg-mg-MP1523-Ab-2; GM-Tg-cynog-MP1523-Ab-1/ GM-Tg-cynog-MP1523-Ab-2;
GM-Tg-felg-MP1523-Ab-1/ GM-Tg-felg-MP1523-Ab-2; GM-Tg-cang-MP1523-Ab-1/ GM-Tg-cang-MP1523-Ab-2;
GM-Tg-bovg-MP1523-Ab-1/ GM-Tg-bovg-MP1523-Ab-2; GM-Tg-equg-MP1523-Ab-1/ GM-Tg-equg-MP1523-Ab-2
Products NameAnti-SIGLEC6 monoclonal antibody
Formatmab
Target NameSIGLEC6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SIGLEC6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SIGL6/ SIGLEC6/ CD327 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1523
    Target NameSIGLEC6
    Gene ID946,719684
    Gene Symbol and SynonymsCD327,CD33L,CD33L1,CD33L2,CDW327,OBBP1,SIGLEC6
    Uniprot AccessionO43699
    Uniprot Entry NameSIGL6_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000105492
    Target ClassificationN/A

    The target: SIGLEC6, gene name: SIGLEC6, also named as CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1. This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.