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Anti-SGCE/ DYT11/ ESG monoclonal antibody
Anti-SGCE/ DYT11/ ESG antibody for FACS & in-vivo assay
Go to SGCE/SGCE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1512-Ab-1/ GM-Tg-hg-MP1512-Ab-2 | Anti-Human SGCE monoclonal antibody | Human |
| GM-Tg-rg-MP1512-Ab-1/ GM-Tg-rg-MP1512-Ab-2 | Anti-Rat SGCE monoclonal antibody | Rat |
| GM-Tg-mg-MP1512-Ab-1/ GM-Tg-mg-MP1512-Ab-2 | Anti-Mouse SGCE monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1512-Ab-1/ GM-Tg-cynog-MP1512-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SGCE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1512-Ab-1/ GM-Tg-felg-MP1512-Ab-2 | Anti-Feline SGCE monoclonal antibody | Feline |
| GM-Tg-cang-MP1512-Ab-1/ GM-Tg-cang-MP1512-Ab-2 | Anti-Canine SGCE monoclonal antibody | Canine |
| GM-Tg-bovg-MP1512-Ab-1/ GM-Tg-bovg-MP1512-Ab-2 | Anti-Bovine SGCE monoclonal antibody | Bovine |
| GM-Tg-equg-MP1512-Ab-1/ GM-Tg-equg-MP1512-Ab-2 | Anti-Equine SGCE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1512-Ab-1/ GM-Tg-hg-MP1512-Ab-2; GM-Tg-rg-MP1512-Ab-1/ GM-Tg-rg-MP1512-Ab-2; GM-Tg-mg-MP1512-Ab-1/ GM-Tg-mg-MP1512-Ab-2; GM-Tg-cynog-MP1512-Ab-1/ GM-Tg-cynog-MP1512-Ab-2; GM-Tg-felg-MP1512-Ab-1/ GM-Tg-felg-MP1512-Ab-2; GM-Tg-cang-MP1512-Ab-1/ GM-Tg-cang-MP1512-Ab-2; GM-Tg-bovg-MP1512-Ab-1/ GM-Tg-bovg-MP1512-Ab-2; GM-Tg-equg-MP1512-Ab-1/ GM-Tg-equg-MP1512-Ab-2 |
| Products Name | Anti-SGCE monoclonal antibody |
| Format | mab |
| Target Name | SGCE |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SGCE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SGCE/ DYT11/ ESG VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001282 | human SGCE Lentivirus plasmid |
| ORF Viral Vector | vGMLP001282 | human SGCE Lentivirus particle |
| ORF Viral Vector | pGMLPm001767 | mouse Sgce Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001767 | mouse Sgce Lentivirus particle |
Target information
| Target ID | GM-MP1512 |
| Target Name | SGCE |
| Gene ID | 8910,20392,432360,700104,475233,101089844,407209,100051775 |
| Gene Symbol and Synonyms | DYT11,e-SG,epsilon-SG,ESG,SGCE |
| Uniprot Accession | O43556,Q6YAT4,Q29S03 |
| Uniprot Entry Name | SGCE_HUMAN,SGCE_RAT,SGCE_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000127990 |
| Target Classification | N/A |
The target: SGCE, gene name: SGCE, also named as DYT11, ESG, epsilon-SG. This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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