Anti-SEZ6/ BSRPC monoclonal antibody

Anti-SEZ6/ BSRPC antibody for FACS & in-vivo assay

Target products collectionGo to SEZ6/SEZ6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1508-Ab-1/ GM-Tg-hg-MP1508-Ab-2Anti-Human SEZ6 monoclonal antibodyHuman
GM-Tg-rg-MP1508-Ab-1/ GM-Tg-rg-MP1508-Ab-2Anti-Rat SEZ6 monoclonal antibodyRat
GM-Tg-mg-MP1508-Ab-1/ GM-Tg-mg-MP1508-Ab-2Anti-Mouse SEZ6 monoclonal antibodyMouse
GM-Tg-cynog-MP1508-Ab-1/ GM-Tg-cynog-MP1508-Ab-2Anti-Cynomolgus/ Rhesus macaque SEZ6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1508-Ab-1/ GM-Tg-felg-MP1508-Ab-2Anti-Feline SEZ6 monoclonal antibodyFeline
GM-Tg-cang-MP1508-Ab-1/ GM-Tg-cang-MP1508-Ab-2Anti-Canine SEZ6 monoclonal antibodyCanine
GM-Tg-bovg-MP1508-Ab-1/ GM-Tg-bovg-MP1508-Ab-2Anti-Bovine SEZ6 monoclonal antibodyBovine
GM-Tg-equg-MP1508-Ab-1/ GM-Tg-equg-MP1508-Ab-2Anti-Equine SEZ6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1508-Ab-1/ GM-Tg-hg-MP1508-Ab-2; GM-Tg-rg-MP1508-Ab-1/ GM-Tg-rg-MP1508-Ab-2;
GM-Tg-mg-MP1508-Ab-1/ GM-Tg-mg-MP1508-Ab-2; GM-Tg-cynog-MP1508-Ab-1/ GM-Tg-cynog-MP1508-Ab-2;
GM-Tg-felg-MP1508-Ab-1/ GM-Tg-felg-MP1508-Ab-2; GM-Tg-cang-MP1508-Ab-1/ GM-Tg-cang-MP1508-Ab-2;
GM-Tg-bovg-MP1508-Ab-1/ GM-Tg-bovg-MP1508-Ab-2; GM-Tg-equg-MP1508-Ab-1/ GM-Tg-equg-MP1508-Ab-2
Products NameAnti-SEZ6 monoclonal antibody
Formatmab
Target NameSEZ6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SEZ6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SEZ6/ BSRPC VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1508
    Target NameSEZ6
    Gene ID124925,20370,192247,710932,491175,101084326,539038,100072101
    Gene Symbol and SynonymsBSRP-C,BSRPC,D11Bhm177e,sez-6,SEZ6
    Uniprot AccessionQ53EL9,A0JNA2
    Uniprot Entry NameSEZ6_HUMAN,SEZ6_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000063015
    Target ClassificationN/A

    The target: SEZ6, gene name: SEZ6, also named as BSRPC. The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.