Anti-RYR2/ ARVC2/ ARVD2 monoclonal antibody

Anti-RYR2/ ARVC2/ ARVD2 antibody for FACS & in-vivo assay

Target products collectionGo to RYR2/RYR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1478-Ab-1/ GM-Tg-hg-MP1478-Ab-2Anti-Human RYR2 monoclonal antibodyHuman
GM-Tg-rg-MP1478-Ab-1/ GM-Tg-rg-MP1478-Ab-2Anti-Rat RYR2 monoclonal antibodyRat
GM-Tg-mg-MP1478-Ab-1/ GM-Tg-mg-MP1478-Ab-2Anti-Mouse RYR2 monoclonal antibodyMouse
GM-Tg-cynog-MP1478-Ab-1/ GM-Tg-cynog-MP1478-Ab-2Anti-Cynomolgus/ Rhesus macaque RYR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1478-Ab-1/ GM-Tg-felg-MP1478-Ab-2Anti-Feline RYR2 monoclonal antibodyFeline
GM-Tg-cang-MP1478-Ab-1/ GM-Tg-cang-MP1478-Ab-2Anti-Canine RYR2 monoclonal antibodyCanine
GM-Tg-bovg-MP1478-Ab-1/ GM-Tg-bovg-MP1478-Ab-2Anti-Bovine RYR2 monoclonal antibodyBovine
GM-Tg-equg-MP1478-Ab-1/ GM-Tg-equg-MP1478-Ab-2Anti-Equine RYR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1478-Ab-1/ GM-Tg-hg-MP1478-Ab-2; GM-Tg-rg-MP1478-Ab-1/ GM-Tg-rg-MP1478-Ab-2;
GM-Tg-mg-MP1478-Ab-1/ GM-Tg-mg-MP1478-Ab-2; GM-Tg-cynog-MP1478-Ab-1/ GM-Tg-cynog-MP1478-Ab-2;
GM-Tg-felg-MP1478-Ab-1/ GM-Tg-felg-MP1478-Ab-2; GM-Tg-cang-MP1478-Ab-1/ GM-Tg-cang-MP1478-Ab-2;
GM-Tg-bovg-MP1478-Ab-1/ GM-Tg-bovg-MP1478-Ab-2; GM-Tg-equg-MP1478-Ab-1/ GM-Tg-equg-MP1478-Ab-2
Products NameAnti-RYR2 monoclonal antibody
Formatmab
Target NameRYR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RYR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RYR2/ ARVC2/ ARVD2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1478
    Target NameRYR2
    Gene ID6262,20191,689560,717179,403615,101084482,537376,100057437
    Gene Symbol and Synonyms9330127I20Rik,ARVC2,ARVD2,RyR,RYR-2,RYR2,VACRDS,VTSIP
    Uniprot AccessionQ92736,B0LPN4
    Uniprot Entry NameRYR2_HUMAN,RYR2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000198626
    Target ClassificationN/A

    The target: RYR2, gene name: RYR2, also named as ARVC2, ARVD2, RYR-2, RyR, VTSIP. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.