Anti-PTPRM/ PTPRL1/ R-PTP-MU monoclonal antibody

Anti-PTPRM/ PTPRL1/ R-PTP-MU antibody for FACS & in-vivo assay

Target products collectionGo to PTPRM/PTPRM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1432-Ab-1/ GM-Tg-hg-MP1432-Ab-2Anti-Human PTPRM monoclonal antibodyHuman
GM-Tg-rg-MP1432-Ab-1/ GM-Tg-rg-MP1432-Ab-2Anti-Rat PTPRM monoclonal antibodyRat
GM-Tg-mg-MP1432-Ab-1/ GM-Tg-mg-MP1432-Ab-2Anti-Mouse PTPRM monoclonal antibodyMouse
GM-Tg-cynog-MP1432-Ab-1/ GM-Tg-cynog-MP1432-Ab-2Anti-Cynomolgus/ Rhesus macaque PTPRM monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1432-Ab-1/ GM-Tg-felg-MP1432-Ab-2Anti-Feline PTPRM monoclonal antibodyFeline
GM-Tg-cang-MP1432-Ab-1/ GM-Tg-cang-MP1432-Ab-2Anti-Canine PTPRM monoclonal antibodyCanine
GM-Tg-bovg-MP1432-Ab-1/ GM-Tg-bovg-MP1432-Ab-2Anti-Bovine PTPRM monoclonal antibodyBovine
GM-Tg-equg-MP1432-Ab-1/ GM-Tg-equg-MP1432-Ab-2Anti-Equine PTPRM monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1432-Ab-1/ GM-Tg-hg-MP1432-Ab-2; GM-Tg-rg-MP1432-Ab-1/ GM-Tg-rg-MP1432-Ab-2;
GM-Tg-mg-MP1432-Ab-1/ GM-Tg-mg-MP1432-Ab-2; GM-Tg-cynog-MP1432-Ab-1/ GM-Tg-cynog-MP1432-Ab-2;
GM-Tg-felg-MP1432-Ab-1/ GM-Tg-felg-MP1432-Ab-2; GM-Tg-cang-MP1432-Ab-1/ GM-Tg-cang-MP1432-Ab-2;
GM-Tg-bovg-MP1432-Ab-1/ GM-Tg-bovg-MP1432-Ab-2; GM-Tg-equg-MP1432-Ab-1/ GM-Tg-equg-MP1432-Ab-2
Products NameAnti-PTPRM monoclonal antibody
Formatmab
Target NamePTPRM
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTPRM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PTPRM/ PTPRL1/ R-PTP-MU VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1432
    Target NamePTPRM
    Gene ID5797,19274,29616,722426,480203,101080832,536092,100059664
    Gene Symbol and SynonymshR-PTPu,mKIAA4044,PTPRL1,PTPRM,R-PTP-MU,RPTPM,RPTPmu,RPTPU
    Uniprot AccessionP28827
    Uniprot Entry NamePTPRM_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000173482
    Target ClassificationN/A

    The target: PTPRM, gene name: PTPRM, also named as PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.